المنشورات و المؤلفات

Blood Brain Barrier (BBB) permeability is frequently compromised in the course of diseases affecting the central nervous system (CNS). Sucrose is a low molecular weight, hydrophilic marker with slow permeability at the naive BBB and therefore one of...
Among small, hydrophilic drug-like molecules, [14C]sucrose has long been considered the gold standard for determination of blood-brain barrier permeability. However, we have recently shown in rats that, compared with liquid chromatography–tandem...
Introduction Blood-brain barrier (BBB) integrity is a critical parameter in the understanding of many CNS disorders. Currently, one of the most commonly used markers for measuring BBB permeability of hydrophilic small molecules is [14C] sucrose....
  The HLA-A2 restricted T-cell receptor mimic (TCRm) antibody RL6A has been shown to have antitumor effects in a breast cancer orthotopic xenograft model with MDA-MB-231 cells. Transgenic mice expressing HLA-A2 also take up RL6A into brain across...