Simultaneous determination of dopamine and uric acid in presence of high concentration of ascorbic acid using cetyltrimethylammonium bromide–polyaniline/activated charcoal composite
Journal Article
, Mani Govindasamy, Shen-Ming Chen, veerappan mani, Anandraj Sathiyan, Princy Merlin, Al-Hemaid Fahad M.A. and Ajmal Ali . 2016
Publication Work Type:
Research Work
Publication Online URL:
Magazine \ Newspaper:
RSC Advances
Issue Number:
DOI: 10.1039/C6RA18740D
Volume Number:
DOI: 10.1039/C6RA18740D
Pages:
RSC Adv., 2016
Publication Abstract:
We described a simple, low-cost and mass producible composite made up of cetyltrimethylammonium bromide (CTAB) functionalized polyaniline (PANI) and activated charcoal (CTAB–PANI/AC) for simultaneous determination of dopamine (DA) and uric acid (UA). The composite formation was verified through scanning electron microscopy, electrochemical impedance spectroscopy and electrochemical methods. The CTAB–PANI/AC composite was used to modify glassy carbon electrode (GCE) and the resulting modified electrode displayed excellent electrocatalytic activity to DA and UA and successfully separates their overlapped voltammetric peaks. The composite completely inhibits the AA signal and does not produce any voltammetric signal for AA upto 2 mM. The DA and UA can be selectively detectable upto detection limits of 0.06 (± 0.006) µM and 0.20 (± 0.008) µM, respectively. The effect of kinetics, analyte concentrations and pH of the supporting electrolyte pH investigated and optimized. The modified electrode has appreciable stability, repeatability and reproducibility. Besides, practical feasibility of the sensor is demonstrated in biological samples which delivered satisfactory recovery results.