Hierarchically CuFe2O4 nanodots entrapped with RGO nanosheets for detection of oxidative stress biomarkers in biological samples
, Shen-Ming Chena, Umamaheswari Rajajia, Mani Govindasamya, Tse-Wei Chena, M.A. Ali*, Fahad M. A. Al-Hemaid, M.S. Elshikh, M. Abul Farah . 2018
In this work, stable and catalytically active copper ferrite nanodots (CuFe2O4) entrapped by porous RGO
nanosheets were prepared via a facile condensation process using a green reducing agent. The composite
was characterized by HR-TEM, EDX, XRD, Raman, TGA, and electrochemical methods. Oxidative stress
caused by the imbalance between oxidants and antioxidant defenses is implicated in many pathological
conditions including age-related disorders, cancer, and cardiovascular, inflammatory, neurodegenerative
and neuropsychiatric diseases. 3-Nitrotyrosine is an electrochemically active biomarker of oxidative stress;
hence its electrochemical determination is useful to set up a sensitive analytical tool for oxidative stress
measurement. The electrocatalytic activities of a CuFe2O4@RGO composite modified electrode toward
3-nitrotyrosine were studied in detail. A rapid, sensitive, selective and reproducible electrochemical
sensing platform was developed for the detection and quantification of 3-nitrotyrosine under neutral pH
conditions. Remarkably, the limit of detection was found to be 25.14 pM, which surpassed the detection
limits of many existing analytical methods. The practical applicability of the method was demonstrated in
human urine and blood serum samples.
The binary nanomaterials and graphitic carbon-based hybrid has been developed as an important porous nanomaterial for fabricating electrode with applications in non-enzymatic (bio) sensors.
An efficient electrochemical sensing and catalysis platform based on Cu–Ni alloy is developed. The Cu–Ni alloy (CN) are synthesized using ultrasonic aided thermal annealing process. The…
In the present work, we reported a one pot simple colloidal–gel synthesis of molybdenum bismuth vanadate (MoBiVO4). The charge transfer property of MoBiVO4 was improved by developing a composite…