Evaluation of anti-nociceptive, anti-inflammatory and antipyretic potential of Mikania cordata in experimental animal model
, Siddiqui, S.A., Atiqur Rahman, M. Oliur Rahman, M. Ahsanul Akbar, A. S. Shamsur Rouf , M.A. Ali, Fahad M.A. Al-Hemaid, Mohammad Abul Farah . 2018
Mikania cordata is widely used for the treatment of cuts, wounds, and dengue fever in Bangladesh. In the
present study, essential oil (12.5, 25 and 50 mg/kg) and two extracts, viz., chloroform and ethyl acetate
extracts (200, 400, 800 mg/kg b.w.) were tested for peripheral and central anti-nociceptive activity by
acetic acid-induced writhing and hot plate method, respectively. Carrageenan-induced rat paw edema
assay and yeast-induced hyperthermia assay were also carried out to evaluate anti-inflammatory and
antipyretic properties of oil and extracts, respectively at aforesaid doses. The essential oil (50 mg/kg),
chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) showed potent peripheral antinociceptive
activity having 47.33%, 29.33% and 16.65% of writhing inhibition, respectively, comparable
with standard diclofenac (52.0%). Essential oil (50 mg/kg), chloroform extract (800 mg/kg) and ethyl acetate
extract (800 mg/kg) presented promising central anti-nociceptive activity as well having 95.86%,
79.18% and 42.37% elongation of reaction time, respectively, at 90 min after administration of essential
oil, ethyl acetate extract and 60 min after administration of chloroform extract. In anti-inflammatory
activity screening, the essential oil (50 mg/kg) produced the highest 72.80% edema inhibition at 4 h after
administration of carrageenan which was comparable with that of standard phenylbutazoe (87.87%). On
the other hand, chloroform extract (800 mg/kg) and ethyl acetate extract (800 mg/kg) showed up to
34.31% and 15.27% of edema inhibition, respectively, at 4 h after administration of carrageenan. In antipyretic
assay, the essential oil and chloroform extract displayed a strong antipyretic effect in yeastinduced
rats, whereas the ethyl acetate extract had no antipyretic activity. The present study revealed
anti-nociceptive, anti-inflammatory and antipyretic potential of M. cordata which could be the therapeutic
option against fever, inflammations as well as painful conditions and confirmed the traditional use of
M. cordata.
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