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Ali Abdullah Alshatwi

Professor

Faculty

كلية علوم الأغذية والزراعة
Building No. 2, Second Floor, 44
المنشورات
مقال فى مجلة
2014

Evaluation of Antiobesity Effect of Mangiferin in Adipogenesis-Induced Human Mesenchymal Stem Cells by Assessing Adipogenic Genes

Alshatwi, P. Subash-Babu and Ali A. . 2014

We aimed to examine the anti-adipogenic effects of mangiferin (xanthone glucoside) and its related mechanism. Human mesenchymal stem cells (hMSCs) were cultured in Dulbecco's modified Eagle medium, after 60% confluence adipocyte differentiation was induced. Differentiation-induced hMSCs were cultured in the presence and absence of 10, 20 and 40 μmol of mangiferin from day 0 to day 10. Adipocyte differentiation and lipid accumulation were significantly decreased in 40 μmol mangiferin-treated groups when compared with the reference drugs (quercetin- and orlistat-treated groups). Using quantitative reverse transcription polymerase chain reaction, we studied the mRNA expression levels of resistin, adipocyte fatty acid-binding protein 2 (aP2), lipoprotein lipase (LPL), peroxisome proliferator-activated receptor (PPAR-γ) and tumor necrosis factor-α, in hMSCs undergoing adipocyte differentiation; treatment with mangiferin attenuated the expression of those adipogenic genes and decreased adipocyte differentiation. Mangiferin significantly inhibited hMSCs to preadipocyte differentiation within the first 2 days of treatment, indicating that the anti-adipogenic effects of mangiferin are achieved through the inhibition of differentiation and maturation.

رقم المجلد
39
رقم الانشاء
1
مجلة/صحيفة
Journal of Food Biochemistry
الصفحات
28–38
مزيد من المنشورات
publications

We aimed to examine the anti-adipogenic effects of mangiferin (xanthone glucoside) and its related mechanism. Human mesenchymal stem cells (hMSCs) were cultured in Dulbecco's modified Eagle medium…

بواسطة P. Subash-Babu and Ali A. Alshatwi
2014
publications

Gastric ulcer is an illness that affects a great number of people worldwide. The goal of the present research was to assess the anti-ulcerogenic activity of nymphayol (NYM), isolated from Nymphaea…

بواسطة Antonisamy P, Subash-Babu P, Alshatwi AA, Aravinthan A, Ignacimuthu S, Choi KC, Kim JH
2014
publications

Nymphaea stellata (Willd.) has been used in traditional medicine for centuries to treat several illnesses, including diabetes. However, scientific evidence supporting its mechanism of action is…

بواسطة Subash-Babu P, Ignacimuthu S, Alshatwi AA
2015