3D calculation of radiation-induced second cancer risk including dose and tissue response heterogeneities

Journal Article

Timlin, Claire . 2015

• Publication Online URL: http://scitation.aip.org/content/aapm/journal/medphys/42/2/10.1118/1.4905158
• Magazine \ Newspaper: MedPhys
• Volume Number: 42
• Pages: 866

Publication Abstract

Tools for comparing relative induced second cancer risk, to inform choice of radiotherapy treatment plan, are becoming increasingly necessary as the availability of new treatment modalities expands. Uncertainties, in both radiobiological models and model parameters, limit the confidence of such calculations. The aim of this study was to develop and demonstrate a software tool to produce a malignant induction probability (MIP) calculation which incorporates patient-specific dose and allows for the varying responses of different tissue types to radiation.