Investigating conversion of malignant induction probability to cancer mortality

Conference Paper

Madkhali, A M . 2014

• Publication Work Type: Poster
• Tags: Modelling, secondary cancer, risk
• Conference Name: ESTRO 33
• Conference Location: Vienna, Austria
• Conference Date: Friday, April 4, 2014
• Sponsoring Organization: ESTRO

Publication Abstract

More than half of cancer patients receive radiotherapy for radical or palliative purposes. Increasing survival rates in cancer patients make it important to study late side-effects, including secondary radiation-induced cancers. Although a number of predictive models exist, the absolute accuracy of these models in the radiotherapy dose range is limited partly due to scarcity of data and partly by extrapolation beyond historical data bounds. The aim of this work is to investigate transforming modelled absolute malignant induction probabilities into life time excess relative risk estimates for cancer-related death (ERR) to allow comparison of the results with the relevant risk estimates in Life Span Study (LSS) report no. 14.