The effect of mean dose or voxel-wise calculation in prediction of radiation-induced secondary cancers

Conference Paper

Madkhali, A M . 2015

• Publication Work Type: Poster
• Conference Name: ESTRO 3rd Forum
• Conference Location: Barcelona, Spain
• Conference Date: Friday, April 24, 2015
• Sponsoring Organization: ESTRO

Publication Abstract

More than half of cancer patients receive radiotherapy for radical or palliative purposes. Increasing survival rates in cancer patients make it important to study late side-effects, including secondary radiation-induced cancers. Although a number of predictive models exist, the absolute accuracy of these models in the radiotherapy dose range is limited partly due to scarcity of data and partly by extrapolation beyond historical data bounds. One of the challenges faced with applying models to the highly spatially varying dose distributions produced in modern radiotherapy is dose heterogeneity within organs at risk. The aim of this work is to investigate the difference between using mean dose (MD) and high-resolution voxel-by-voxel dose (VbV) maps for calculating malignant induction probability (MIP).