Screening and evaluation of antioxidant activity of some 1, 2, 4-triazolo [1, 5-a] quinazoline derivatives
Abuelizz, Rashad Al-Salahi, El-Hassane Anouar, Mohamed Marzouk, Hanan AA Taie, Hatem A . 2017
Aim: The present study was carried out to assess a new series of triazoloquinazolines 1–40 for their antioxidant activities using 1,1-diphenyl-2-picryl hydrazyl radical scavenging, ferric reduction antioxidant power and reducing power capability assays. Results: All triazoloquinazolines 1–40exhibited antioxidant activity ranged from weak to moderate and high. The obtained findings revealed that the triazoloquinazolines 30, 36 and 38–40 have superiority among all compounds, demonstrating the highest capacity to deplete 1,1-diphenyl-2-picryl hydrazyl and free radicals, in relation to butylated hydroxyl toluene, as a synthetic antioxidant agent. Conclusion: Chemical modifications together with density functional theory study on the targets supplied us with some valuable clarifications about the required properties needed for the target compounds to be more active against free radicals.
The pseudoglycosyltransferase (PsGT) VldE is a glycosyltransferase-like protein that is similar to trehalose 6-phosphate synthase (OtsA). However, in contrast to OtsA, which catalyzes condensation…
The title compound, C18H20N4O2S2, is a new 1,3,4-oxadiazole and a key pharmacophore of several biologically active agents. It is composed of a methyl(thiophen-2-yl)-1,3,4-oxadiazole-2(3H…
C31H36F2N6S, monoclinic, P21/c (no. 14), a = 14.7561(8) Å, b = 24.6766(13) Å, c = 7.7811(4) Å, β = 95.888(2)°, V = 2818.4(3) Å3, …