Solubility and thermodynamic function of apremilast in different (Transcutol + water) cosolvent mixtures: Measurement, correlation and molecular interactions
Alsarra, Ibrahim A. . 2017
Abstract
The solubility of apremilast (APM) in different “Transcutol® + water” cosolvent mixtures was determined and correlated at “T = 298.2 K–318.2 K” and ‘p = 0.1 MPa’. The experimental solubilities of APM were determined and correlated with “Apelblat, van’t Hoff, Yalkowsky and Jouyban–Acree equations”. The maximum solubilities of APM in mole fraction were obtained in neat Transcutol (2.53 × 10−2 at T = 318.2 K). Based on activity coefficients, strong molecular interactions were obtained between APM and neat Transcutol in comparison with APM and neat water. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of APM
نوع عمل المنشور
Research Paper
رقم الانشاء
56
مجلة/صحيفة
Journal of Industrial and Engineering Chemistry
الصفحات
from 99 to 107
مزيد من المنشورات
Abstract
2017
Abstract
2017