Histological Changes in the Liver and Intestine of Nile Tilapia, Oreochromis niloticus, Exposed to Sublethal Concentrations of Cadmium
Younis, El-Sayed Mohamed . 2013
Abstract.- Cadmium (Cd) is one of the most harmful heavy metal pollutants in aquatic environments.
Fingerlings of Nile tilapia, Oreochromis niloticus, were exposed to sublethal concentrations (10, 20 and 30% of the
96-h LC50) CdCl2 which caused significant changes in concentration dependent manner in the hepatic and ileal tissues.
The hepatic tissue lost its characteristic architecture, with increased vacoulations in hepatocytes. In addition, abundant
eythrocytic infiltration was observed in the 10% of LC50 group and clearly increased in the 20% of LC50 group.
Increase of hemorrhage, vacuolation in hepatocytes and infiltration of sinusoids with leukocytes were observed in the
30% of LC50 group. The intestinal tissue in the treated groups was characterized by increased degenerated nuclei and
apoptosis in crypts of Lieberkuhn, in addition to abnormally dilated lamina propria infiltrated with a large number of
inflammatory leukocytes and disturbance of the longitudinal muscularis. Goblet cells increased in all treated groups,
indicating a defense mechanism against the severe pathological changes induced. In conclusion, severe damage to the
hepatic and intestinal tissues of the Nile tilapia was observed upon contamination of the fish environment with CdCl2.
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