Simultaneous Imaging of Two Different Cancer Biomarkers Using Aptamer-Conjugated Quantum Dots.

Journal Article

Kim, Jonghwan Lee, Hyo Kang,.; Jang, H.; Lee, Y.J.; Lee, Y.S.; Ali, B.A.; Abdulaziz Al-Khedhairy, Soonhag . 2015

• Publication Work Type: Research Article
• Magazine \ Newspaper: Sensors
• Volume Number: 15
• Pages: 8595-8604

Publication Abstract

Studying gene expression profile in a single cancer cell is important because

multiple genes are associated with cancer development. Quantum dots (QDs) have been

utilized as biological probes for imaging and detection. QDs display specific optical and

electrical properties that depend on their size that can be applied for imaging and sensing

applications. In this study, simultaneous imaging of the cancer biomarkers, tenascin-C and

nucleolin, was performed using two types of aptamer-conjugated QDs. The simultaneous

imaging of these two different cancer markers in three cancer cell lines was reliable and cell

line-specific. Current requirements for cancer imaging technologies include the need for

simple preparation methods and the ability to detect multiple cancer biomarkers and evaluate