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Dina Mahmoud Ahmed Hasanin

Associate Professor

Faculty member

كلية العلوم
Building 5,3rd floor,office 114
المنشورات
مقال فى مجلة
2020

Impact of Coenzyme Q10 Administration on Lead AcetateInduced Testicular Damage in Rats

Moneim, Manal El-khadragy , Wafa A. Al-Megrin,1 Norah A. AlSadhan, Dina M. Metwally , Rehab E. El-Hennamy, Fatma Elzahraa H. Salem, Rami B. Kassab , and Ahmed E. Abdel . 2020

Exposure to lead (Pb) causes multiorgan dysfunction including reproductive impairments. Here, we examined the protective effects of coenzyme Q10 (CoQ10) administration on testicular injury induced by lead acetate (PbAc) exposure in rats. This study employed four experimental groups (n = 7) that underwent seven days of treatment as follows: control group intraperitoneally (i.p.) treated with 0.1 ml of 0.9% NaCl containing 1% Tween 80 (v : v), CoQ10 group that was i.p. injected with 10 mg/kg CoQ10, PbAc group that was i.p. treated with PbAc (20 mg/kg), and PbAc+CoQ10 group that was i.p. injected with CoQ10 2 h after PbAc. PbAc injection resulted in increasing residual Pb levels in the testis and reducing testosterone, luteinizing hormone, and follicle-stimulating hormone levels. Additionally, PbAc exposure resulted in significant oxidative damage to the tissues on the testes. PbAc raised the levels of prooxidants (malondialdehyde and nitric oxide) and reduced the amount of endogenous antioxidative proteins (glutathione and its derivative enzymes, catalase, and superoxide dismutase) available in the cell. Moreover, PbAc induced the inflammatory response as evidenced by the upregulation of inflammatory mediators (tumor necrosis factor-alpha and interleukin-1 beta). Further, PbAc treatment induced apoptosis in the testicular cells, as indicated by an increase in Bax and caspase 3 expression, and reduced Bcl2 expression. CoQ10 supplementation improved testicular function by inhibiting Pb accumulation, oxidative stress, inflammation, cell death, and histopathological changes following PbAc exposure. Our findings suggest that CoQ10 can act as a natural therapeutic agent to protect against the reproductive impairments associated with PbAc exposure.

مجلة/صحيفة
Oxidative Medicine and Cellular Longevity
الصفحات
12
مزيد من المنشورات
publications

Malaria is an important health problem in subtropical and tropical areas around the world. Infection with protozoan parasites of the Plasmodium genus, which grow inside host erythrocytes, causes…

2021
publications

Sarcocystis spp. are intracellular protozoan parasites with an intermediate-definitive host life cycle based on a prey–predator relationship. Sarcocystis infection is common among different…

2021
publications

Arsenic is a potent neurotoxic xenobiotic found in drinking water, and food. Chlorogenic acid (CGA), an abundant polyphenol in coffee, potentially has a wide range of therapeutic benefits.

بواسطة Dina M. Metwallya,b,c , Reem A. Alajmia , Manal F. El-Khadragyd,e,⁎ , Hany M. Yehiaf,g , Wafa A. AL-Megrind , Ahmed M.A. Akabawyh , Hatem K. Aminh , Ahmed E. Abdel Moneim
2020