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Dr. rer. nat Elsayed Ahmed Elsayed

Associate Professor

Faculty Staff Member

كلية العلوم
Building 5, AB107
المنشورات
مقال فى مجلة
2016

Synthesis, characterization and cytotoxicity evaluation of 5-hydrazono-[1,2,4]triazolo[1,5-a]quinazolines (Part I).

Marzouk., Rashad Al-Salahi, Elsayed A. Elsayed, Rabab A. El Dib, Mohammad Wadaan, Esam Ezzeldin & Mohamed . 2016

In a continuation of and update to our research on the synthesis and biological evaluation of 1,2,4-triazolo[1,5-a]quinazolines, this study deals with a new series of their 5-hydrazono-[1,2,4]triazolo[1,5-a]quinazolines (1-19) that was synthesized by the reaction of 5-hydrazino-[1,2,4]triazoloquinazolines with a variety of aryl(hetero)aldehydes. Their cytotoxic effects have been evaluated in vitro in relation to human breast MCF-7, hepatocellular Hep-G2, human cervical HeLa and mouse fibroblast L929 cancer cell lines, using MTT assay. The obtained IC50-values are reported in μg/mL and μM, using gemcitabine hydrochloride as a reference drug. The findings revealed that compound 11 had significant cytotoxic effects against all four cell lines. Its IC50 values ranged between 18.7 and 191.4 μg/mL in relation to gemcitabine hydrochloride (IC50 = 169.6–365.3 μg/mL). However, 6, 13, 14 and 15 showed remarkable significant effect against MCF-7 cell line and 13 and 15 against L929. Compound 6 was found to exhibit the highest activity against Hela cell line. 

رقم المجلد
35
رقم الانشاء
1
مجلة/صحيفة
Lat. Am. J. Pharm
الصفحات
58-65
مزيد من المنشورات
publications

Background: Pectinase enzymes present a high priced category of microbial enzymes with many potential applications in various food and oil industries and an estimated market share of $ 41.4…

بواسطة El Enshasy, Elsayed EA, Suhaimi N, MalekRA, Esawy M
2018
publications

A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer
agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-…

بواسطة El-Naggar M, El-Shorbagi A-N, El-Naggar D, Amr AE, Al-Omar M, Elsayed EA
2018
publications

Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) constitutes an improtant microbial enzyme with wide applications in differnt food and pharmaceutical sectors. The present work used…

بواسطة Elsayed EA, El Enshasy HA
2018