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Dr. rer. nat Elsayed Ahmed Elsayed

Associate Professor

Faculty Staff Member

كلية العلوم
Building 5, AB107
المنشورات
مقال فى مجلة
2017

Anti-ovarian and anti-breast cancers with dual topoisomerase ii/braf600e inhibitors activities of some substituted indole derivatives

Elsayed, Abd El-Galil E. Amr, Mohamed M. Abdalla, Mohamed A. Al-Omar, Elsayed A. . 2017

We here in report the anti-cancer and kinases inhibitor activities of some substituted indole derivatives 1-10. which were synthesized and evaluated as analgesic and anticonvulsant agents before. Ten compounds were conveniently screened for their in vitro cytoyoxicity against a wide rannge of cell lines; these compounds showed potent activities against ovarian and breast cancer cell lines. The in vivo antiovrian cancer and anti-breast cancer of the most active in vitro compounds were estimated and founded highly potent. In search for the mechanism of action of anticancer activities it was found that these
compounds exert their action via Topoisomerase II inhibition and inhibition of BRAF600E

نوع عمل المنشور
Research Article
رقم المجلد
28
رقم الانشاء
1
مجلة/صحيفة
Biomedical Research
الصفحات
75-80
مزيد من المنشورات
publications

Background: Pectinase enzymes present a high priced category of microbial enzymes with many potential applications in various food and oil industries and an estimated market share of $ 41.4…

بواسطة El Enshasy, Elsayed EA, Suhaimi N, MalekRA, Esawy M
2018
publications

A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer
agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-…

بواسطة El-Naggar M, El-Shorbagi A-N, El-Naggar D, Amr AE, Al-Omar M, Elsayed EA
2018
publications

Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) constitutes an improtant microbial enzyme with wide applications in differnt food and pharmaceutical sectors. The present work used…

بواسطة Elsayed EA, El Enshasy HA
2018