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Dr. rer. nat Elsayed Ahmed Elsayed

Associate Professor

Faculty Staff Member

كلية العلوم
Building 5, AB107
المنشورات
مقال فى مجلة
2017

Synthesis and Antimicrobial Activities of Some Novel Substituted Dihydropyrido[2,3-g]quinoline Candidates

Elsayed, Salwa F. Mohamed, Hanaa M. Hosni, Nehad A. Abdel Latif, Abd El-Galil E. Amr, and Elsayed A. . 2017

A series of substituted pyridinium candidates 2–11 were synthesized and tested as antimicrobial activities by using 4,9-di(3-methoxyphenyl)-2,7-dioxo-1,2,5,6,7,10-hexahydropyrido[2,3-g]quinoline-3,8-dicarbonitrile (1) as starting material. Treatment of cyanopyridione 1 with ethyl chloroacetate afforded bis-ethyl ester derivative 2, which was fused with anthranilic acid to give oxazin-4-on-3,8-dicarbonitrile derivative 3. Condensation of 2 with hydrazine hydrate afforded acid hydrazide 4, which was refluxed with aromatic aldehydes in ethanol to give the corresponding hydrazone derivatives
5(a)–(c), respectively. The latter compounds 5(a)–(c) was condensed with thioglycollic acid to afford thiazolo derivatives 6(a)–(c), respectively. Reaction of hydrazide 4 with phenylisothiocyanate, ethyl acetoacetate or a mixture of glacial acetic acid and acetic anhydride to give compounds 7, 9 and 10, respectively. Compounds 7 or 10 were cyclized with chloroacetic acid or ethyl cyanoacetate to afford thiazolo-8 and pyridine 11 derivatives, respectively. Several products showed remarkable antimicrobial activities comparable with Streptomycin and Fusidic acid as standard drugs 

نوع عمل المنشور
Research Article
رقم المجلد
14
رقم الانشاء
11
مجلة/صحيفة
Journal of Computational and Theoretical Nanoscience
الصفحات
5378–5385
مزيد من المنشورات
publications

Background: Pectinase enzymes present a high priced category of microbial enzymes with many potential applications in various food and oil industries and an estimated market share of $ 41.4…

بواسطة El Enshasy, Elsayed EA, Suhaimi N, MalekRA, Esawy M
2018
publications

A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer
agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-…

بواسطة El-Naggar M, El-Shorbagi A-N, El-Naggar D, Amr AE, Al-Omar M, Elsayed EA
2018
publications

Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) constitutes an improtant microbial enzyme with wide applications in differnt food and pharmaceutical sectors. The present work used…

بواسطة Elsayed EA, El Enshasy HA
2018