Synthesis, Characterization and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates

Journal Article
EA, El-Naggar M, El-Shorbagi A-N, El-Naggar D, Amr AE, Al-Omar M, Elsayed . 2018
Publication Work Type: 
Research Article
Magazine \ Newspaper: 
J. Chem.
Volume Number: 
2018
Pages: 
3626824
Publication Abstract: 

A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer
agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl
afforded diazonium salt derivatives 2 and 5, which were treated with substituted imino or substituted amino derivatives, to give the
corresponding substituted amino-pent-2-en-3-yl-diazenylbenzoate 4a–k or 2-substituted-1-(naphthalen-1-yl)diazene derivatives
6a–h, 7a,b, and 8a,b. All the synthesized compounds were elucidated by elemental analysis and spectroscopic evidence.