المنشورات و المؤلفات
A series of substituted pyridinium candidates 2–11 were synthesized and tested as antimicrobial activities by using 4,9-di(3-methoxyphenyl)-2,7-dioxo-1,2,5,6,7,10-hexahydropyrido[2,3-g]quinoline-3,8-dicarbonitrile (1) as starting material. Treatment...
In the process of profiling the secondary metabolites of actinobacteria isolated from the Saudi coastal habitats for production of antibiotics and anti-cancer drugs, the cultures of strain WH1 that was identified as Streptomyces heliomycini...
Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) is a highly glycosylated enzyme which hydrolyzes sucrose
to glucose and fructose. Therefore, it finds many applications in food and feed industries. In addition, this enzyme become
more...
Cordyceps is one of the components of traditional Chinese medicine. This mushroom becomes worldwide famous due to its significant therapeutic effects on various diseases. Nucleoside like cordycepin, a major bioactive compound from Cordyceps...
Kefiran is a functional fermented milk product traditionally used for its beneficial probiotic properties. It exhibits antimicrobial, antioxidant, anti-inflammatory anticancer and different health promoting characteristics. Although kefiran showed...
We here in report the anti-cancer and kinases inhibitor activities of some substituted indole derivatives 1-10. which were synthesized and evaluated as analgesic and anticonvulsant agents before. Ten compounds were conveniently screened for their in...
Alpha amylase (E.C. 3.2.1.1) is one of the most important starch-degrading enzymes and widely applied in pharmaceutical, food, feed, detergent, textile and bio refinery industries. The present work was focused on optimization of -amylase production...
Lactobacillus kefiranofaciens is non-pathogenic gram positive bacteria isolated from kefir grains and able to produce extracellular exopolysaccharides named kefiran. This polysaccharide contains approximately equal amounts of glucose and galactose....
The emergence of a large number of antimicrobialresistant organisms is a cause for concern. Nature is historically the source of drugs; indeed a considerable number of drugs have been developed from microorganisms, and are now used daily in the...
Azotobacter vinelandii is a model free-living diazotroph, which converts atmospheric nitrogen into ammonia in the presence of atmospheric oxygen. During the last decades, extensive work has been carried out to study the genetic and metabolic...
Moringa peregrina belongs to the Moringaceae family and is native to the western part of Saudi Arabia and the eastern part of Egypt, from where it has been transferred to tropical and subtropical countries. The Moringa trees are highly appreciated...
Human gastrointestinal microbiota (HGIM) incorporate a large number of microbes from different species. Anaerobic bacteria are the dominant organisms in this microbial consortium and play a crucial role in human health. In addition to
their...
The great demand for animal feed additives is directly proportional to the increased world human population. Such increase in demand has inspired scientists to look for alternatives to traditional feed additives in order to cope with the increased...
A new 5-hydrazono[1,2,4]triazolo[1,5-a]quinazoline series was synthesized by the reaction of 5-hydrazino[1,2,4]-triazoloquinazoline with different aryl(hetero)ketones or acid anhydrides and their structures were established using NMR and HREI-MS...
In a continuation of and update to our research on the synthesis and biological evaluation of 1,2,4-triazolo[1,5-a]quinazolines, this study deals with a new series of their 5-hydrazono-[1,2,4]triazolo[1,5-a]quinazolines (1-19) that was synthesized...
Oxytetracycline (OTC) production by Streptomyces rimosus was studied in batch and fed-batch cultures in shake flask and bioreactor levels using semi-defined medium. First, the effect of glucose concentration on OTC production and growth kinetics...
N-Heterocyclic carbene (NHC) metal complexes possess diverse biological activities but have yet to be extensively explored as potential chemotherapeutic agents. We have previously reported the synthesis of a new class of NHC metal complexes N-...
Fructooligosaccharides have been mainly produced by microbial fructosyltransferases (FTase) enzymes. The present work focuses on the optimization of medium composition and cultivation parameters affecting FTase produced by Penicillium ...
Moringa oleiferaLam. (Moringaceae) is widely consumed in tropical and subtropical regions for their valuable nutritional and medicinal characteristics. Recently, extensive research has been conducted on leaf extracts of M. oleifera to evaluate their...
Development of cultivation medium for high yield kefiran production by Lactobacillus kefiranofaciens
Objective: Kefiran is one of the important microbial polysaccharides of many pharmaceutical and nutraceutical applications. It shows many potential medical applications as antimicrobial and immunomodulatory compound. The present work focuses on...
Rifamycins are broad spectrum and important antibiotics used in the treatment of pathogenic diseases. They are generally produced by the fermentative cultivation of Amycolatopsis mediterranei, using submerged cultivation
system. The...
Lactobacillus delbrueckii sp. bulgaricus WICC-B-02 is new probiotic strain which was initially isolated from the mother’s milk. As lactic acid bacterium, it’s known as a highly efficient probiotic microorganism with a wide range of benefits...
For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also...
The process for high cell mass and spore production by Bacillus thuringiensis var israelensis (Bti) on semi-industrial scale was developed. Cultivations were conducted in shake flask and bioreactor levels to develop a semi-industrial scale process...
Phytase production using Escherichia coliBL21 (DE3), a recombinant strain harboring a plasmid encoding thermostable Bacillusphytase, in semi-industrial scale was studied in this work. Among the factors needed to be considered in order to achieve ...
Since their introduction, nucleoside analogues such as acyclovir are considered to be effective antiviral drugs against viral infections caused by herpes simplex. However, with the emergence of acyclovir-resistance, there is a growing need to...
This report involves the production of Au/Ag core–shell nanoparticles that were incorporated into cubic aluminum zeolite ([Al]-ZSM-5) and their test towards the microbial activity. The produced nanocomposite was characterized by X-ray diffractometry...
Introduction:A new method for preparation of silver nanoparticles (AgNPs) based on using hydrazino-isatin derivatives in an aqueous methanol reaction medium is reported here. AgNPs were prepared using silver nitrate solubilized in a water core as...
This study was focused on the investigation of the kinetics of cell growth and oxytetracycline (OTC) production during the cultivation of Streptomyces rimosusin submerged culture in different scales using semi-defined cultivation medium. In shake ...
Monoclonal antibodies (Mabs) have been recently used for the treatment of virtually every debilitating disease. Packed-bed bioreactors have been used for the cultivation and production of a wide range of cell lines and biologics including MAbs. The...
Natamycin is an important tetraene (polyene) antibiotic produced in submerged culture by different strains of Streptomyces sp. In the present work, the effects of the addition of short-chain carboxylic acids (acetic, ...
The ethnopharmaceutical approach is important for the discovery and development of natural product research and requires a deep understanding not only of biometabolites discovery and profiling but also of cultural and social science. For millennia,...
Background: Hepatocellular carcinoma is one of the leading causes of mortalities worldwide. The search for new therapeutic targets is of utmost importance for improved treatment. Altered expression of HDAC1 in hepatocellular carcinoma (HCC) and its...
In this study, a new amylase producer strain was isolated from sweet potato tuber. This strain was able to grow at 37 °C and produce α-amylase in high quantity compared to other standard strain cultures. In the first part, cultivation in shake flask...
This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold...
The effect of pumphead type and operating pressure on cell viability and cell separaion efficiency was investigated during hydrocyclone separation recombinant CHO cells producing human GM-CSF.