Publications

Background: Pectinase enzymes present a high priced category of microbial enzymes with many potential applications in various food and oil industries and an estimated market share of $ 41.4 billion by 2020. Results: The production medium was first...
A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl...
Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) constitutes an improtant microbial enzyme with wide applications in differnt food and pharmaceutical sectors. The present work used the biotherapeutic yeast Saccharomyces boulardii to...
Tyrosinase (EC 1.14.18.1, monophenol, O-diphenol: oxygen oxidoreductase) is a copper-metallo-bifunctional enzyme, which catalyzes the O-hydroxylation and oxidation of monophenols to quinones. Tyrosinase plays an important role in the immune defense...
A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N,N-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine 1a,b as starting material. Structures of the newly synthesized compounds were established by IR, 1H and...
A series of estrone derivatives, 2–4, were synthesized from the corresponding arylidine estrone, 2a, b, as starting materials, which were prepared by condensation of estrone (3-hydroxy-estran-17-one, 1) with 4-bromobenzaldehyde and thiophene-2-...
Nowadays, nanotechnology is widely applied for the development of highly efficient products in the pharmaceutical and cosmetic industries. Converting bioactive materials to nanoscale not only increases their biocompatibility but also increases their...
Levan is an extracellular polysaccharide composed of fructose (fructans) that has wide applications as antitumor, antioxidant, and antiviral properties. It shows important therapeutic effects as an anticancer agent with fibrinolytic action. The...
A series of substituted pyridinium candidates 2–11 were synthesized and tested as antimicrobial activities by using 4,9-di(3-methoxyphenyl)-2,7-dioxo-1,2,5,6,7,10-hexahydropyrido[2,3-g]quinoline-3,8-dicarbonitrile (1) as starting material. Treatment...
In the process of profiling the secondary metabolites of actinobacteria isolated from the Saudi coastal habitats for production of antibiotics and anti-cancer drugs, the cultures of strain WH1 that was identified as Streptomyces heliomycini...
Invertase (β-D-fructofuranoside fructohydrolase; EC 3.2.1.26) is a highly glycosylated enzyme which hydrolyzes sucrose to glucose and fructose. Therefore, it finds many applications in food and feed industries. In addition, this enzyme become more...
Cordyceps is one of the components of traditional Chinese medicine. This mushroom becomes worldwide famous due to its significant therapeutic effects on various diseases. Nucleoside like cordycepin, a major bioactive compound from Cordyceps...
Kefiran is a functional fermented milk product traditionally used for its beneficial probiotic properties. It exhibits antimicrobial, antioxidant, anti-inflammatory anticancer and different health promoting characteristics. Although kefiran showed...
We here in report the anti-cancer and kinases inhibitor activities of some substituted indole derivatives 1-10. which were synthesized and evaluated as analgesic and anticonvulsant agents before. Ten compounds were conveniently screened for their in...
Alpha amylase (E.C. 3.2.1.1) is one of the most important starch-degrading enzymes and widely applied in pharmaceutical, food, feed, detergent, textile and bio refinery industries. The present work was focused on optimization of -amylase production...
Lactobacillus kefiranofaciens is non-pathogenic gram positive bacteria isolated from kefir grains and able to produce extracellular exopolysaccharides named kefiran. This polysaccharide contains approximately equal amounts of glucose and galactose....
The emergence of a large number of antimicrobialresistant organisms is a cause for concern. Nature is historically the source of drugs; indeed a considerable number of drugs have been developed from microorganisms, and are now used daily in the...
Azotobacter vinelandii is a model free-living diazotroph, which converts atmospheric nitrogen into ammonia in the presence of atmospheric oxygen. During the last decades, extensive work has been carried out to study the genetic and metabolic...
Moringa peregrina belongs to the Moringaceae family and is native to the western part of Saudi Arabia and the eastern part of Egypt, from where it has been transferred to tropical and subtropical countries. The Moringa trees are highly appreciated...
Human gastrointestinal microbiota (HGIM) incorporate a large number of microbes from different species. Anaerobic bacteria are the dominant organisms in this microbial consortium and play a crucial role in human health. In addition to their...
The great demand for animal feed additives is directly proportional to the increased world human population. Such increase in demand has inspired scientists to look for alternatives to traditional feed additives in order to cope with the increased...
A new 5-hydrazono[1,2,4]triazolo[1,5-a]quinazoline series was synthesized by the reaction of 5-hydrazino[1,2,4]-triazoloquinazoline with different aryl(hetero)ketones or acid anhydrides and their structures were established using NMR and HREI-MS...
In a continuation of and update to our research on the synthesis and biological evaluation of 1,2,4-triazolo[1,5-a]quinazolines, this study deals with a new series of their 5-hydrazono-[1,2,4]triazolo[1,5-a]quinazolines (1-19) that was synthesized...
Oxytetracycline (OTC) production by  Streptomyces rimosus  was studied in batch and fed-batch cultures in shake flask and bioreactor levels using semi-defined medium. First, the effect of glucose concentration on OTC production and growth kinetics...
N-Heterocyclic carbene (NHC) metal complexes possess diverse biological activities but have yet to be extensively explored as potential chemotherapeutic agents. We have previously reported the synthesis of a new class of NHC metal complexes N-...
Fructooligosaccharides have been mainly produced by microbial fructosyltransferases (FTase) enzymes. The present work focuses on the optimization of medium composition and cultivation parameters affecting FTase produced by Penicillium ...
Moringa oleiferaLam. (Moringaceae) is widely consumed in tropical and subtropical regions for their valuable nutritional and medicinal characteristics. Recently, extensive research has been conducted on leaf extracts of M. oleifera to evaluate their...
Objective: Kefiran is one of the important microbial polysaccharides of many pharmaceutical and nutraceutical applications. It shows many potential medical applications as antimicrobial and immunomodulatory compound. The present work focuses on...
Rifamycins are  broad spectrum and important antibiotics used in the treatment of  pathogenic diseases. They are generally  produced  by  the  fermentative  cultivation  of  Amycolatopsis  mediterranei,  using  submerged  cultivation  system. The...
Lactobacillus delbrueckii  sp. bulgaricus  WICC-B-02  is new probiotic strain which  was initially isolated from the mother’s milk.  As lactic acid bacterium, it’s known as a  highly efficient  probiotic microorganism with a wide range of benefits...
For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also...
The process for high cell mass and spore production by Bacillus thuringiensis var israelensis (Bti) on semi-industrial scale was developed. Cultivations were conducted in shake flask and bioreactor levels to develop a semi-industrial scale process...
Phytase production using Escherichia coliBL21 (DE3), a recombinant strain harboring a plasmid encoding thermostable Bacillusphytase, in semi-industrial scale was studied in this work. Among the factors needed to be considered in order to achieve ...
Since their introduction, nucleoside analogues such as acyclovir are considered to be effective antiviral drugs against viral infections caused by herpes simplex. However, with the emergence of acyclovir-resistance, there is a growing need to...
This report involves the production of Au/Ag core–shell nanoparticles that were incorporated into cubic aluminum zeolite ([Al]-ZSM-5) and their test towards the microbial activity. The produced nanocomposite was characterized by X-ray diffractometry...
Introduction:A new method for preparation of silver nanoparticles (AgNPs) based on using hydrazino-isatin derivatives in an aqueous methanol reaction medium is reported here. AgNPs were prepared using silver nitrate solubilized in a water core as...
This study was focused on the investigation of the kinetics of cell growth and oxytetracycline (OTC) production during the cultivation of Streptomyces rimosusin submerged culture in different scales using semi-defined cultivation medium. In shake ...
Monoclonal antibodies (Mabs) have been recently used for the treatment of virtually every debilitating disease. Packed-bed bioreactors have been used for the cultivation and production of a wide range of cell lines and biologics including MAbs. The...
Natamycin  is  an  important  tetraene  (polyene)  antibiotic  produced  in  submerged  culture  by  different strains  of  Streptomyces  sp.  In  the  present  work,  the  effects  of  the  addition  of  short-chain  carboxylic  acids (acetic,  ...
The ethnopharmaceutical approach is important for the discovery and development of natural product research and requires a deep understanding not only of biometabolites discovery and profiling but also of cultural and social science. For millennia,...
Background: Hepatocellular carcinoma is one of the leading causes of mortalities worldwide. The search for new therapeutic targets is of utmost importance for improved treatment. Altered expression of HDAC1 in hepatocellular carcinoma (HCC) and its...
In this study, a new amylase producer strain was isolated from sweet potato tuber. This strain was able to grow at 37 °C and produce α-amylase in high quantity compared to other standard strain cultures. In the first part, cultivation in shake flask...
This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold...
The effect of pumphead type and operating pressure on cell viability and cell separaion efficiency was investigated during hydrocyclone separation recombinant CHO cells producing human GM-CSF.