Protective Effect of Curcumin on γ-radiation Induced Chromosome Aberrations in Human Blood Lymphocytes. Saudi Journal of Biological Science

Journal Article

AlSuhaibani, Entissar Suliman . 2009

• نوع عمل المنشور: ورقة بحثية
• المجلة \ الصحيفة: Saudi Journal of Biological Science
• رقم العدد: 16
• رقم الإصدار السنوي: 3
• الصفحات: 33-39

مستخلص المنشور

The present work is aimed at evaluating the radioprotective effect of curcumin on γ-radiation induced genetic toxicity. The DNA damage was analyzed by the frequencies of chromosome aberrations  assay. Human lymphocytes were treated in vitro with 5.0 μg/ml of curcumin for 30 min at 37 °C then exposed to 1, 2 and 4 Gy gamma-radiation. The lymphocytes which were pre-treated with curcumin exhibited a significant decrease in the frequency of chromosome aberration at 1 and 2 Gy radiation-induced chromosome damage as compared with the irradiated cells which did not receive the curcumin pretreatment. Thus, pretreatment with curcumin gives protection to lymphocytes against γ-radiation induced chromosome aberration at certain doses.