Protective effect of aspirin on γ radiation-induced sperm malformations in Swiss Albino male mice
, Marowa Mansour AlMathkour . 2014
This study evaluated the effects of γ radiation on spermatozoa based on the morphological characteristics of
sperm in the caudal epididymis of SWR/J mice. In this study, various abnormal sperm shapes (amorphous heads, hook-less,
mid-piece defect, pinheads, coiled tails, and tail-less) were observed after exposure to γirradiation (2 or 4 Gy)and after
treatment with aspirin (ASA) and γ-irradiation (0.5 mg/kg + 2 or 4 Gy, 5 mg/kg + 2 or 4 Gy and 50 mg/kg + 2 or 4 Gy).
The higher rate of abnormal sperm forms was observed in the γ-irradiated mice compared with the aspirin + γ-irradiationtreated
mice. In addition, the numberof sperm with amorphous heads and coiled tails wassignificantly increasedafter
irradiation. This study suggests that ASA can effectively reducethe effects of 2to4-Gy radiationin sperm. However, further
studies are needed elucidate the mechanisms underlying the antioxidant effect of ASA.
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