In vitro antimicrobial activity of some medicinal plants found in Saudi Arabia
Perveen, Kahkashan . 2014
he methanolic extracts of
Citrullus colocynthis, Rhazya
stricta,
Datura
stramonium
and
Zygophyllum coccineum
were evaluated for the antimicrobial activity
against
Pseudomonas aeruginosa
ATCC 27853,
Escherichia coli
ATCC 25922,
Staphylococcus aureus
ATCC 25928,
Streptococcus pyogenes
grp A (clinical isolate),
Bacillus subtilis
ATCC 6633 and
Candida albicans
ATCC 10231
.
The extract of different
plants tested showed varying degree of inhibitory activity against the tested pathogens.
Extract of
C. colocynthis
showed the highest activity followed by
R. stricta,
while
Z.
coccineum
exhibited least activity. The gram positive bacteria were observed to be more
sensitive to plant extracts as compare to gram negative bacteria. Moreover, all extract
were effective against
C. albicans
. While, only the extract of
C. colocynthis
was able to
inhibit the growth of
P. aeruginosa
(18.3 mm). The maximum zone of inhibition was
observed against
S. aureus
(31.3mm) by the extract of
C. colocynthis
and the MIC against
the same bacteria was 0.2 mg/ml. The GCMS analysis of
C. colocynthis
extract showed the
presence of several esters, glycosides, alkaloids and flavonoids. However, the main
component detected in the extract was l-(+)-Ascorbic acid 2,6-dihexadecanoate; a known
hyaluronidase inhibitor. Therefore, the results showed that
C. colocynthis
possesses a
broad spectrum of activity against pathogenic bacteria responsible for the most common
microbial diseases
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