تجاوز إلى المحتوى الرئيسي
User Image

Farid Shokry Ataya

Associate Professor

Teaching Staff Member

كلية العلوم
2A26 Building 5
المنشورات
مقال فى مجلة
2016

Al-Jafari A, Daoud MS Ataya FS. ACE Gene Insertion/Deletion Polymorphism in Coronary Artery Disease in the Saudi Population. Archives of Applied Science Research, 2016, 8 (3):4-10. ISSN 0975-508X,

Genetic factors play a pivotal role in the development and pathogenesis of coronary artery disease (CAD). The angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism is one of the various genetic factors associated with CAD. In this study, we investigated the association between the ACE gene I/D polymorphism and CAD in the Saudi population. A total of 210 CAD patients were studied, while 103 age-matched healthy adults were used as control subjects. ACE I/D polymorphism was detected by lectrophoresing the amplified PCR ACE product on an agarose gel, and several biochemical and behavioral markers were monitored.In the CAD group, we determined that the DD genotype frequency was 65.7%, whereas 27.6% of the patients carried the ID genotype, and 6.7% carried the II genotype. Within the control group, 57.3% carried the DD genotype, 25.2% carried the ID genotype, and 17.5%carried the II genotype. The odds ratio (OR) of the ACE genotype ID versus the II notype at a 95% confidence interval (CI) was 2.87 (1.24-6.63, p <0.01), and the OR of the DD versus the II genotype at a 95% CI was 3.01 (1.40-6.44, p <0.004). Our results provide a significant association between the ID and DD ACE polymorphisms in CAD patients in the Saudi population.

رقم المجلد
8
مجلة/صحيفة
Archives of Applied Science Research
الصفحات
4-10
مزيد من المنشورات
publications

Glutathione S. transferases (GSTs; EC. 2.5.1.18) are a large family of multifunctional enzymes that play crucial roles in the metabolism and inactivation of a broad range of xenobiotic compounds.…

بواسطة Fereniki Perperopoulou, Nirmal Poudel, Anastassios C. Papageorgiou, Farid Ataya and Nikolaos E
2022
تم النشر فى:
MPDI
publications

Background: In the wake of the warning by WHO that the prevalence of dementia may have a rise of 125% in the Middle East by 2050, identification of the genetic risk factors in Arab populations is…

بواسطة Saba Abdi, Amani Ahmed Alghamdi, Nouf Nasser Abduallah AlGhunaim, Reem Muteb Almutairi, Farid Shokry Ataya, Mohammed Ghouse Ahmed Ansari, Syed Danish Hussain, Mohammad Masoud, Abir Alamro,Othman T. Almutairi, Nasser M. Al-Daghri, Taim Abdullah Muayqil
2022
تم النشر فى:
Current Pharmaceutical Biotechnology