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Fowad Khurshid فؤاد خورشيد

Lecturer

Lecturer at Department of Clinical Pharmacy محاضر بقسم الصيدلة الاكلينيكية

كلية الصيدلة
College of Pharmacy, Department of Clinical Pharmacy مكتب : كلية الصيدلة-قسم الصيدلة الاكلينيكية-الدور الاول
المنشورات
مقال فى مجلة
2018

Effect of Centella asiatica Formulation on the Pharmacokinetics of Amitriptyline in Rats: A Herb-Drug Interaction Study

, Fowad KHURSHID, Jeyabalan GOVINDASAMY, Habibullah KHALILULLAH, Mohammed Shivli NOMANI, Mudassar SHAHID , Md Ruhal AIN & Mohammad S. ALSULTAN . 2018

SUMMARY. This study evaluates the effect of Centella asiatica formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each) which were served as a control (amitriptyline alone) and treatment group (amitriptyline with C. asiatica), respectively. Rats were administered vehicle saline or C. asiatica (62.5 mg/kg, p.o. daily for 7 days), then administered a single amitriptyline dose (25 mg/kg, p.o.) on day 8. Plasma samples were analyzed for amitriptyline concentration using a developed and validated reversed-phase high-performance liquid chromatography (RPHPLC) method. Pharmacokinetic parameters were calculated using non-compartmental analysis. The coadministration of C. asiatica with amitriptyline resulted in increased plasma maximum concentration (Cmax), area under the curve (AUC0–24) and elimination half-life (t1/2) by 14.34, 23, and 13.81%, respectively. The present study demonstrated that C. asiatica extract has the potential to alter the pharmacokinetics of amitriptyline by a significant reduction in amitriptyline clearance and an increase in its AUC, Cmax and t1/2.

رقم المجلد
37
رقم الانشاء
4
مجلة/صحيفة
Lat. Am. J. Pharm.
الصفحات
663-70
مزيد من المنشورات
publications

Purpose: This study aimed to explore the physician’s knowledge and identify the perceived barriers that prevent family medicine physicians from engaging in deprescribing among older  patients.

بواسطة Maha M Alrasheed, Tariq M Alhawassi, Alanoud Alanazi, Nouf Aloudah, Fowad Khurshid, Mohammed Alsultan;
2018
publications

SUMMARY. This study evaluates the effect of Centella asiatica formulation on the pharmacokinetics of amitriptyline in rats. In this study, rats were randomly divided into two groups (n = 6 each)…

بواسطة Fowad KHURSHID, Jeyabalan GOVINDASAMY, Habibullah KHALILULLAH, Mohammed Shivli NOMANI, Mudassar SHAHID , Md Ruhal AIN & Mohammad S. ALSULTAN
2018
publications

Interactions between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Experimental data on the pharmacokinetic interactions between herbal…

بواسطة Fowad Khurshid, Jeyabalan Govindasamy, Habibullah Khalilullah, Mohammed Shivli Nomani, Mudassar Shahid, Md Ruhal Ain, Mohammad Sultan Alsultan
2017