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Muhammad Farooq khan

Associate Professor

Associate professor of Cell and molecular Biology

كلية العلوم
College of Science, building S5 Lab # 1B44 (zebrafish lab)
المنشورات
مقال فى مجلة
2014

Synthesis and biological activity of Schiff base series of valproyl, N-valproyl glycinyl, and N-valproyl-4-aminobenzoyl hydrazide derivatives

, 13. Ayman El-Faham, Muhammad Farooq, Sherine N. KhattabAhmed M. Elkayal, Mahmoud F. Ibrahim, Nael Abu Taha, Mohammad A. M. Wadaan, Ezaat A. Hamed. . 2014

valproic acid; valproic acid hydrazide; Schiff base; antiangiogenic activity; anticancer activity

Series of Schiff bases of valproic acid hydrazide,

N

-valproylglycine hydrazide and

N

-valproyl-4-ami

-

nobenzoyl hydrazide derivatives were synthesized and characterized by IR, NMR (

1

H- and

13

C-NMR) and

elemental analysis. The prepared compounds were evaluated in transgenic zebrafish embryos (Tg:

flil-1

: en

-

hanced green fluorescent protein (EGFP)) for antiangiogenic activity and in HepG2 liver carcinoma cell line

for anti cancer activity. The Schiff bases of

N

-valproylglycine hydrazide derivatives were most potent in term

of suppressing angiogenic blood vessels formation and anticancer activity at very low concentration, followed

by the Schiff bases of valproic acid hydrazide derivatives which exhibited moderate activity, while the Schiff

bases of

N

-valproyl-4-aminobenzoyl hydrazide derivatives, ethyl 4-(2-propylpentanamido)benzoate (VABE)

and

N

-(4-(hydrazinecarbonyl)phenyl)-2-propylpentanamide (VABH) in contrast exhibited pro-angiogenic

activity and weaker anticancer activity which mean that these derivatives targeted a common signaling path

-
way in term of affecting the blood vessels formatio

نوع عمل المنشور
Research article
رقم المجلد
62
رقم الانشاء
6
مجلة/صحيفة
Chem. Pharm. Bull.
الصفحات
591–599
مزيد من المنشورات
publications

The study was designed to find out the protein complex(s) associated with HDAC3 in liver cancer using a modified form of affinity purification coupled with a mass spectrometry technique in HepG2…

بواسطة 15. Muhammad Farooq and Mohammad A.M. Wadaan
2013
publications

Series of Schiff bases of valproic acid hydrazide,

N

-valproylglycine hydrazide and

N

-valproyl-4-ami

-

nobenzoyl hydrazide derivatives were synthesized…

بواسطة 13. Ayman El-Faham, Muhammad Farooq, Sherine N. KhattabAhmed M. Elkayal, Mahmoud F. Ibrahim, Nael Abu Taha, Mohammad A. M. Wadaan, Ezaat A. Hamed.
2014
publications

Pulicaria genus belongs to the family Compositae. Some species of this genus have been used in traditional Arab medicine as antispasmodic agent. In this study the Pulicaria glutinosa, which is a…

بواسطة 12. Nael Abutaha1, Muhammad Farooq, Fahd Abdu Al-Mekhlafi, Baabbad Almohannad, Sabir Shehata and Mohammad Wadaan
2014