DIRECTED LITHIATION AND SUBSTITUTION OF PYRIDINE DERIVATIVES
Journal Article
El-Hiti, Gamal A. . 2015
Publication Work Type:
Review
Publication Online URL:
Magazine \ Newspaper:
Heterocycles
Issue Number:
3
Volume Number:
91
Pages:
479-504
Publication Abstract:
Directed lithiation of substituted pyridines containing a directing metalating group (DMG) with a lithium reagent in anhydrous solvent at low temperature gives the corresponding lithium intermediates in-situ, which on reactions with electrophiles produce the corresponding substituted derivatives. The method is simple, general, convenient and often high yielding