Synthesis of a series of diphenyl (arylamino)(pyridin-3-yl)methylphosphonates as potential antimicrobial agents

Journal Article

El-Hiti, Gamal A. . 2013

• Publication Work Type: Research
• Magazine \ Newspaper: Phosphorus, Sulfur, and Silicon and the Related Elements
• Issue Number: 7
• Volume Number: 188
• Pages: 879-885

Publication Abstract

Series of diphenyl 1-(arylamino)(pyridin-3-yl)methylphosphonates were obtained in high yields from the reactions of nicotinaldehyde with aromatic amines and triphenylphosphite in the presence of titanium tetrachloride as a catalyst. The structures of the synthesized compounds were confirmed by IR, ¹H NMR and mass spectral data and their purities were confirmed by elemental analyses. The synthesized α‑aminophosphonates showed moderate to high antimicrobial activities against Escherichia coli (NCIM2065) as a Gram-negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram-positive bacteria and Candida albicans and Saccharomyces cerevisiae as fungi, at various concentrations (10–100 μg/mL). The lethal dose of the synthesized compounds was also determined and indicated that most compounds are safe to use.