Simple and Convenient Procedure for the Synthesis of 2-(3-(tert-Butoxycarbonylamino)propyl)-5-methylthiophenes

Journal Article

Balakit, Asim A. . 2013

• Publication Online URL: http://www.iasj.net/iasj?func=fulltext&aId=83523
• Magazine \ Newspaper: Iraqi National Journal of Chemistry
• Issue Number: 52
• Pages: 466-476

Publication Abstract

2-(3-(tert-Butoxycarbonylamino)propyl)-5-methylthiophene and its 4-deuterio derivative have been synthesized by a simple and convenient method in a six step sequence from 2-methylthiophene. The final step involved bromine-lithium exchange on 4-bromo-2-(3-(tert-butoxycarbonylamino)propyl)-5-methylthiophene at low temperature in anhydrous tetrahydrofuran followed by treatment with water or D2O.