A simple procedure for synthesis of 3H-quinazolin-4-one hydrazones under mild conditions

Journal Article

Abdel-Megeed, Mohamed F. . 2014

• Publication Work Type: Reserach
• Publication Online URL: http://www.sciencedirect.com/science/article/pii/S1319610311002572
• Magazine \ Newspaper: Journal of Saudi Chemical Society
• Issue Number: 6
• Volume Number: 18
• Pages: 1022-1027

Publication Abstract

Condensation of 6-bromo- and 6,8-dibromo-2-hydrazino-3-phenyl-3H-quinazolin-4-ones with d-sugars in the presence of a catalytic quantity of glacial acetic acid gave the corresponding hydrazones in good yields. Acetylation of hydrazones with acetic anhydride in anhydrous pyridine gave the corresponding acetyl hydrazones in high yields. Also, other hydrazones were synthesized from condensation of 2-hydrazino-3H-quinazolin-4-ones with aromatic aldehydes in the presence of a catalytic quantity of piperidine.