Crystal structure of 3-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-5-(thiophen-2-yl)-1, 3, 4-oxadiazole-2 (3H)-thione

Journal Article
Garcia-Granda, Monirah A Al-Alshaikh, Hatem A Abuelizz, Ali A El-Emam, Mohammed SM Abdelbaky, Santiago . 2016
المجلة \ الصحيفة: 
Acta Crystallographica Section E
مستخلص المنشور: 

The title compound, C18H20N4O2S2, is a new 1,3,4-oxa­diazole and a key pharmacophore of several biologically active agents. It is composed of a meth­yl(thio­phen-2-yl)-1,3,4-oxa­diazole-2(3H)-thione moiety linked to a 2-meth­oxy­phenyl unit via a piperazine ring that has a chair conformation. The thio­phene ring mean plane lies almost in the plane of the oxa­diazole ring, with a dihedral angle of 4.35 (9)°. The 2-meth­oxy­phenyl ring is almost normal to the oxa­diazole ring, with a dihedral angle of 84.17 (10)°. In the crystal, mol­ecules are linked by weak C-H...S hydrogen bonds and C-H...[pi] inter­actions, forming layers parallel to the bc plane. The layers are linked via weak C-H...O hydrogen bonds and slipped parallel [pi]-[pi] inter­actions [inter­centroid distance = 3.6729 (10) Å], forming a three-dimensional structure. The thio­phene ring has an approximate 180° rotational disorder about the bridging C-C bond.