smileysmileysmileysmileysmileysmileysmileyenlightenedenlightenedenlightenedenlightenedenlightenedenlightened

Prof. Abdel Halim HARRATH

King Saud University 

Zoology Department, College of Science

P.O.  Box  2455,  Riyadh  11451 

Saudi  Arabia 

Tel: +966 11 46 75 915

Cell phone: +966 535 862 799

https://fac.ksu.edu.sa/hharrath/home

https://www.researchgate.net/profile/Halim_Harrath

https://www.linkedin.com/profile/view?id=33473682&trk=nav_responsive_tab_profile_pic



























\Habilitation_31_10_2016\websiteHalim\20161207_132904.jpg \Habilitation_31_10_2016\websiteHalim\P2080106.JPG
\Habilitation_31_10_2016\websiteHalim\20160606_163217 (1).jpg\Habilitation_31_10_2016\websiteHalim\P2060045.JPG
My academic career has been involved in several fields of biology and we can consider me as a hybrid. I  have participated in a large-scale multidisciplinary of biology related to both basic and applied research projects.

My Ph.D studies were centered around the comprehension of the mechanisms of reproduction and developmental  biology using the freshwater planarian Schmidtea mediterranea as a model.
//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo1.png//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo2.png//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo3.png//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo4.png OOCYTE-100X.jpg










My postdoctoral studies were balancing between two different fields of research: a) Reproduction and developmental biology and, b) Evolutionary biology. The last research axis which is mainly focusing on the biosystematics and molecular phylogenetics of planarians has been developed under the supervision of Prof. Marta Riutort (University of Barcelona, Spain) and Dr. Ronald Sluys (University of Amsterdam, Netherlands).
I then moved to the King Saud University where I gradually focused my work, with respect to the first field of basic research, in a new direction of applied research: "The fetal programming research". We are particularly interested in the effect of some environmental perturbations, mainly nutrition and pollution, on gametogenesis and pregnancy, and thus on the heath of the new generations. Indeed, the gametogenesis and the early fetal development are critical determinants of adult physiology. In fact, some cases of adulthood diseases can be attributed to an adverse embryonic environment that leads to permanent changes in growth, metabolism and the vasculature of various organs, which predisposes the child to adulthood diseases. We are also interested to expand knowledge about the mechanisms of actions and areas of applications of selected candidate molecules of plant extracts in control of gametogenesis, in particular female reproductive processes. For that, rats and rabbits represent excellent models for studying and testing new drugs. Using these models, we try to examine in vivo and in vitro effects, mechanisms and areas of possible application of plant and seed components in control of different female reproductive processes such as ovarian cell proliferation, ovarian cell apoptosis, ovarian follicle growth and maturation and embryo development.

//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo6.jpg//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo7.png//fac.ksu.edu.sa/sites/default/files/images/10943/medium_photo8.png\Habilitation_31_10_2016\Articles\Mechanims.apop\Fluorescence\IL1_HyperObj10_1.tif\Habilitation_31_10_2016\Articles\Mechanims.apop\Halim\IL-6-hyper-20x-4.tif
COOPERATION

  • Systems Biology Group Lab, Sapienza University of Rome, Rome, Italy

  • Institute of Animal Genetics & Reproduction", Animal Production Research Centre Nitra, Slovakia

  • Evolution and Development Departmenti di Genètica, Facultat de Biologia, Universitat de Barcelona, Spain

  • Institute for Biodiversity and Ecosystem Dynamics (IBED) à l’Université d’Amsterdam




  1. Harrath, A.H., strup O.bRafay J.deKoničková I.dLaurincik J.c, Sirotkin, A.V. 2017. Metabolic state defines the response of rabbit ovarian cells to leptin. In press, Reproductive Biology.

  2. VLCKOVA, R., SOPKOVA, D., ANDREJCAKOVA, Z., VALOCKY, I., KADASI, A., HARRATH, A. H., PETRILLA, V. & SIROTKIN, A. V. 2017. Dietary supplementation of yucca (Yucca schidigera) affects ovine ovarian functions. Theriogenology, 88, 158-165.

  3. Harrath, A.H., Semlali A., Mansour L., Aldahmash W., Al Omar S.Y, Al Anazi M.S., Nyengaard J., Alwasel S. 2017. Dynamics of cytokine-like activity in the hyperplasic ovary of ex-fissiparous planarians. Biological bulletin 232 (1): 1-15.

  4. Sirotkin A.V., Alexa R., Kádasi A., Štochmaľová A., Harrath A., Grossmann R. 2017. The soy isoflavone daidzein directly affects porcine ovarian cell functions and modifies the effect of FSH. J Anim Physiol Anim Nutr 101(1):127-135

  5. BIZZARRI, M., CUCINA, A., DINICOLA, S., HARRATH, A. H., ALWASEL, S. H., UNFER, V. & BEVILACQUA, A. 2016. Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation? Medical Hypotheses, 91, 1-5.

  6. DINICOLA, S., FABRIZI, G., MASIELLO, M. G., PROIETTI, S., PALOMBO, A., MININI, M., HARRATH, A.H., ALWASEL, S. H., RICCI, G., CATIZONE, A., CUCINA, A. & BIZZARRI, M. 2016. Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Experimental Cell Research, 345, 37-50.

  7. DINICOLA, S., PASQUALATO, A., PROIETTI, S., MASIELLO, M. G., PALOMBO, A., COLUCCIA, P., CANIPARI, R., CATIZONE, A., RICCI, G., HARRATH, A. H., ALWASEL, S. H., CUCINA, A. & BIZZARRI, M. 2016. Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by gamma-secretase inhibition. Life Sciences, 145, 174-183.

  8. GAMMOUDI, M., SALVENMOSER, W., HARRATH, A. H., TEKAYA, S. & EGGER, B. 2016. Ultrastructure of spermatogenesis and mature spermatozoa in the flatworm Prosthiostomum siphunculus (Polycladida, Cotylea). Cell Biology International, 40, 277-288.

  9. GAMMOUDI, M., SALVENMOSER, W., TEKAYA, S. & EGGER, B. 2016. Ultrastructure of the ovary and oogenesis in the flatworm Prosthiostomum siphunculus (Polycladida, Cotylea). Cell Biology International, 40, 1174-1186.

  10. KHALED, I., FERJANI, H., BEN AHMED, R. & HARRATH, A. H. 2016. Effects of oil-related environmental pollutants on gonads of the freshwater leech Limnatis nilotica (Annelida, Hirudinea). Invertebrate Reproduction & Development, 60, 263-270.

  11. KLIOSNKY, D., … HARRATH, A. H….. 2016. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015). Autophagy, 12, 443-443.

  12. PASTA, V., DINICOLA, S., GIULIANI, A., HARRATH, A. H., ALWASEL, S. H., TARTAGLIA, F., CUCINA, A. & BIZZARRI, M. 2016. A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women. Breast Cancer-Basic and Clinical Research, 10.

  13. PASTA, V., DINICOLA, S., GIULIANI, A., HARRATH, A. H., ALWASEL, S. H., TARTAGLIA, F., CUCINA, A. & BIZZARRI, M. 2016. A randomized trial of Boswellia in association with betaine and myo-inositol in the management of breast fibroadenomas. European Review for Medical and Pharmacological Sciences, 20, 1860-1865.

  14. SIROTKIN, A. V., HARRATH, A. H. & GROSSMANN, R. 2016. Comparison of the effects of human and chicken ghrelin on chicken ovarian hormone release. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, 201, 59-63.

  15. SIROTKIN, A. V., HARRATH, A. H. & GROSSMANN, R. 2016. The role of metabolic state and obestatin in control of chicken ovarian hormone release. Poultry Science, 95, 1939-1942.

  16. SIROTKIN, A. V., MERTIN, D., SUVEGOVA, K., LAURICIK, J., MOROVIC, M., HARRATH, A. H. & KOTWICA, J. 2016. Mink aging is associated with a reduction in ovarian hormone release and the response to FSH and ghrelin. Theriogenology, 86, 1175-1181.

  17. SIROTKIN, A. V., MESZAROSOVA, M., HARRATH, A. H. & GROSSMANN, R. 2016. Obestatin Directly Controls Chicken Ovarian Cell Functions. Journal of Biological Regulators and Homeostatic Agents, 30, 665-674.

  18. SIROTKIN, A. V., ORAVCOVA, M., SLAMECKA, J., HARRATH, A. H. & RAJSKY, M. 2016. Interrelationships between reproductive cycle, age, body weight and steroid hormones in roe deer females (Capreolus capreolus). Folia Zoologica, 65, 59-64.

  19. Pasta, V., Gullo, G., Giuliani, A., Harrath, A.H., Alwasel, S., Tartaglia, F., Cucina, A. & Bizzarri, M. 2015. An association of boswellia, betaine and myo-inositol (Eumastόs®) in the treatment of mammographic breast density: a randomized, double-bind study. Eur Rev Med Pharmacol Sci. 9(22):4419-26.

  20. Harrath, A.H., Alwasel, s., Khaled, i., Mansour, l., Sirotkin, a.v. and Faramawi, f. 2015.  Pregnancy exposure to atmospheric pollutants and placental weight in a Tunisian population". Fresen. Environ. Bull, 24 (11): 4184-4189”.

  21. Sirotkin, a.v., Kardošová, d., Alwasel, S. & Harrath, a.h. 2015. Neuropeptide Y can directly control ovarian cell proliferation and apoptosis. Rep. Biol. 15(4):257-60.

  22. Al Omar, S.Y, Daoud, A., Alarifi, s., Harrath, A.H., Mansour, l., Alwasel, s., 2015. Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells. Environ. Toxicol. 30 (2): 149-160.

  23. Sirotkin, a.v., Alexa, r., Dekanová, d., Kádasi, a., Štochmaľová, a., Grossmann, r., Alwasel, s. & Harrath, a.H. 2015. The mTOR system can affect basic porcine ovarian cell functions and mediate the effect of ovarian hormonal regulators. Int J Pharmacol, 11 (6), 570-578.

  24. Ben Ali, M., guesmi, F., Harrath, A.H., Alwasel, s., Hedfi, A., Ncib, S., Landoulsi, A., aldahmash, B., Ben-Attia, M. 2015. Investigation of Antiulcer and Antioxidant Activity of Juniperus phoenicea (Cupressaceae) Essential Oil in an Experimental Rat Model. Biol. Pharm. Bull., 38 (11): 1738-1746.

  25. SIROTKIN, A. V., ALEXA, R., KISOVA, G., HARRATH, A. H., ALWASEL, S., OVCHARENKO, D. & MLYNCEK, M. 2015. MicroRNAs control transcription factor NF-kB (p65) expression in human ovarian cells. Funct Integr Genomics, 15, 271-5.

  26. HARRATH, A. H., SEMLALI, A., MANSOUR, L., AHMED, M., SIROTKIN, A. V., AL OMAR, S. Y., ARFAH, M., AL ANAZI, M. S., ALHAZZA, I. M., NYENGAARD, J. R. & ALWASEL, S. 2014. Infertility in the hyperplasic ovary of freshwater planarians: the role of programmed cell death. Cell Tissue Res,. 358, 607-20

  27. Sirotkin, a.v. & HARRATH, A. H.,. 2014. Phytoestrogens and their effects. Eur J Pharmacol, 741: 230-236.

  28. ALI, D., YADAV, P. G., KUMAR, S., ALI, H., ALARIFI, S. & HARRATH, A. H. 2014. Sensitivity of freshwater pulmonate snail Lymnaea luteola L., to silver nanoparticles. Chemosphere, 104, 134-40.

  29. AHMED, M., ALI, D., HARRATH, A. H., HUSSAIN, T., AL-DAGHRI, N., ALOKAIL, M. S., ALADAKATTI, R. H. & GHODESAWAR, M. A. 2014. Ultrastructural and hormonal changes in rat cauda epididymal spermatozoa induced by Boswellia papyrifera and Boswellia carterii. C R Biol, 337, 250-7.

  30. ALWASEL, S. H., HARRATH, A. H., ALDAHMASH, W. M., ABOTALIB, Z., NYENGAARD, J. R., OSMOND, C., DILWORTH, M. R., AL OMAR, S. Y., JERAH, A. A. & BARKER, D. J. 2014. Sex differences in regional specialisation across the placental surface. Placenta, 35, 365-9.

  31. HARRATH, A. H., GAMMOUDI, M., MANSOUR, L., AHMED, M., SIROTKIN, A. V., AL OMAR, S. Y., IBRAHIM, K. E. & ALWASEL, S. H. 2014. Investigation of the ultrastructure of Dendrocoelum constrictum (Platyhelminthes, Tricladida) spermatogenesis and mature spermatozoa. C R Biol, 337, 513-20.

  32. SIROTKIN, A. V., DEKANOVA, P., HARRATH, A. H., ALWASEL, S. H. & VASICEK, D. 2014. Interrelationships between sirtuin 1 and transcription factors p53 and NF-kappaB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell Tissue Res, 358, 627-32.

  33. SIROTKIN, A. V. & HARRATH, A. H. 2014. Phytoestrogens and their effects. Eur J Pharmacol, 741, 230-6.

  34. AHMED, M., AL-DAGHRI, N., HARRATH, A. H., ALOKAIL, M. S., ALADAKATTI, R. H., GHODESAWAR, M. A. & ALWASEL, S. 2013. Potential ultrastructural changes in rat epididymal cell types induced by Boswellia papyrifera and Boswellia carterii incense. C R Biol, 336, 392-9.

  35. ALWASEL, S. H., HARRATH, A., ALJARALLAH, J. S., ABOTALIB, Z., OSMOND, C., AL OMAR, S. Y., KHALED, I. & BARKER, D. J. 2013a. Intergenerational effects of in utero exposure to Ramadan in Tunisia. Am J Hum Biol, 25, 341-3.

  36. ALWASEL, S. H., HARRATH, A. H., ALJARALLAH, J. S., ABOTALIB, Z., OSMOND, C., AL OMAR, S. Y., THORNBURG, K. & BARKER, D. J. 2013b. The velocity of fetal growth is associated with the breadth of the placental surface, but not with the length. Am J Hum Biol, 25, 534-7.

  37. HARRATH, A. H., AHMED, M., SAYED, S. R., SAIFI, M. A. & ALWASEL, S. H. 2013. An ultrastructural study of oogenesis and cell dynamics during cocoon shell secretion in the subterranean freshwater planarian Dendrocoelum constrictum (Platyhelminthes, Tricladida). Tissue Cell, 45, 39-46.

  38. HARRATH, A. H., SLUYS, R., ALDAHMASH, W., AL-RAZAKI, A. & ALWASEL, S. 2013. Reproductive Strategies, Karyology, Parasites, and Taxonomic Status of Dugesia Populations from Yemen (Platyhelminthes: Tricladida: Dugesiidae). Zoological Science, 30, 502-508.

  39. PAVLOVA, S., KLUCSKA, K., VASICEK, D., RYBAN, L., HARRATH, A. H., ALWASEL, S. H. & SIROTKIN, A. V. 2013. The involvement of SIRT1 and transcription factor NF-kappaB (p50/p65) in regulation of porcine ovarian cell function. Anim Reprod Sci, 140, 180-8.

  40. ALWASEL, S. H., ABOTALIB, Z., ALJARALLAH, J. S., OSMOND, C., AL OMAR, S. Y., HARRATH, A., THORNBURG, K. & BARKER, D. J. 2012. The breadth of the placental surface but not the length is associated with body size at birth. Placenta, 33, 619-22.

  41. HARRATH, A. H., ALWASEL, S., ZGHAL, F. & TEKAYA, S. 2012. Ultrastructure of spermatogenesis and mature spermatozoon of the freshwater planarian Schmidtea mediterranea (Platyhelminthes, Paludicola). C R Biol, 335, 87-95.

  42. Sirotkin, V., Kádasi, a., Baláži, a., Baková, z.,  Harrath, a.h., Makarevich, a.v.,  Kolesárová, a., Chrenek, p., Kotwica, j. & Tóth, t. 2012. Influence of petrochemical Industry environmental contaminants on animal ovarian cells. J Micro Biotechnol Food Sci (JMBFS), 2 (3), 517-525.

  43. ALWASEL, S. H., ABOTALIB, Z., ALJARALLAH, J. S., OSMOND, C., ALKHARAZ, S. M., ALHAZZA, I. M., HARRATH, A., THORNBURG, K. & BARKER, D. J. 2011. Secular increase in placental weight in Saudi Arabia. Placenta, 32, 391-4.

  44. LAZARO, E. M., HARRATH, A. H., STOCCHINO, G. A., PALA, M., BAGUNA, J. & RIUTORT, M. 2011. Schmidtea mediterranea phylogeography: an old species surviving on a few Mediterranean islands? BMC Evolutionary Biology, 11, 274.

  45. ALWASEL, S. H., ABOTALIB, Z., ALJARALLAH, J. S., OSMOND, C., ALKHARAZ, S. M., ALHAZZA, I. M., HARRATH, A., THORNBURG, K. & BARKER, D. J. 2011. Sex differences in birth size and intergenerational effects of intrauterine exposure to Ramadan in Saudi Arabia. Am J Hum Biol, 23, 651-4.

  46. HARRATH, A. H., ALWASAL, S. H., ALHAZZA, I., ZGHAL, F. & TEKAYA, S. 2011. An ultrastructural study of oogenesis in the planarian Schmidtea mediterranea (Platyhelminthe, Paludicola). C R Biol, 334, 516-25.

  47. HARRATH, A. H., SLUYS, R., ZGHAL, F. & TEKAYA, S. 2009. First report of adelphophagy in flatworms during the embryonic development of the planarian Schmidtea mediterranea (Benazzi, Baguna, Ballester, Puccinelli & Del Papa, 1975) (Platyhelminthes, Tricladida). Invertebrate Reproduction & Development, 53, 117-124.



General Biology
Advanced Histo-chemistry
General Physiology
There may be regional specialisation in structure and function across the placental surface. In Riyadh, Saudi Arabia, the length and the breadth of the placental surface at birth were...
Toxicity of nanoparticles depends on many factors including size, shape, chemical composition, surface area and surface charge. Silver nanoparticles (AgNPs) are likely to enter the aquatic...
Boswellia papyrifera and Boswellia carterii diffuses smoke polluting air that adversely affects indoor environment that certainly harm human health. Therefore, this study aims at...