المنشورات و المؤلفات

UPLC-ESI-MS/MS study of the effect of green tea extract on the oral bioavailability of erlotinib and lapatinib in rats: potential risk of pharmacokinetic interaction

Comparative pharmacokinetic profiles of selected irreversible tyrosine kinase inhibitors, neratinib and pelitinib, with apigenin in rat plasma by UPLC-MS/MS

tNeratinib (NER) and pelitinib (PEL) are irreversible tyrosine kinase inhibitors (TKIs) that have beenrecently employed in cancer treatment. Apigenin (API), among other flavonoids, is known to haveantioxidant, anti-proliferative, and carcinogenic...

Simultaneous estimation of four new direct acting antiviral agents in pharmaceutical formulations by HPLC-DAD method

Background: Ombitasvir/paritaprevir/ritonavir/dasabuvir (Viekira Pak®) are the newest medicines approved for use in the treatment of hepatitis C virus (HCV) and are available in tablet form as an oral combination. Specifically, these agents are...

Simultaneous determination of erlotinib and tamoxifen in rat plasma using UPLC-MS/MS: application to pharmacokinetic interaction studies

Tamoxifen (TAM) is a non-steroidal estrogen receptor antagonist that enhances erlotinib (ERL)-inducedcytotoxicity in the treatment of NSCLC. ERL and TAM are metabolized by CYP3A4 enzymes. In addition,both drugs have the potential of altering the...

An eco-friendly direct spectrofluorimetric method for the determination of irreversible tyrosine kinase inhibitors, neratinib and pelitinib: application to stability studies

A new rapid and simple stability-indicating spectrofluorimetric method has been developed for the determination of two irreversible tyrosine kinase inhibitors (TKIs), neratinib (NER) and pelitinib (PEL). The method is based upon measurement of the...

Simultaneous determination of selected tyrosine kinase inhibitorswith corticosteroids and antiemetics in rat plasma by solid phaseextraction and ultra-performance liquid chromatography–tandemmass spectrometry: Application to pharmacokinetic interactionstu

Derivative emission spectrofluorimetry for the simultaneous determination of guaifenesin and phenylephrine hydrochloride in pharmaceutical tablets

Microemulsion electrokinetic chromatography with polarity switching stacking mode for the determination of dexamethasone and dexamethasone sodium phosphate: application to pharmacokinetic studies in rabbit plasma

Determination of luteolin and apigenin in herbs by capillary electrophoresis with diode array detection

Chemometrics-assisted spectrofluorimetric determination of two co-administered drugs of major interaction, methotrexate and aspirin, in human urine following acid-induced hydrolysis

Isolation of flavonoids from Delonix elata and determination of its rutin content using capillary electrophoresis

Determination of methyl gallate in Bauhinia retusa extract by high-performance liquid and thin layer chromatography

Simultaneous determination of dexamethasone and lenalidomide in rat plasma by solid phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry: application to pharmacokinetic studies

Development of Validated Chromatographic Methods for the Simultaneous Determination of Metronidazole and Spiramycin in Tablets

GC-MS and GC-IRD studies on brominated dimethoxyamphetamines: Regioisomers related to 4-Br-2,5-DMA (DOB)

Development and validation of a stability-indicating HPLC-DAD method with ANN optimization for the determination of diflunisal and naproxen in pharmaceutical tablets

Non-parametric linear regression of discrete Fourier transform convoluted chromatographic peak responses in non-ideal conditions