Fish Cholinesterases as Biomarkers of Sublethal Effects of Organophosphorus and Carbamates in Tissues of Labeo Rohita

Journal Article

Ahmad2, Ghazala,1 Shahid Mahboob,2,3 L. Ahmad,3 S. Sultana,3 K. Al-Ghanim,2 F. Al-Misned,2 and Z. . 2014

• Publication Work Type: Profenofos; Carbofuran; Acetylcholinesterase; Butyrylcholinesterase; Inhibition
• Publication Online URL: Journal of Biochemical and Molecular Toxicology
• Tags: Profenofos; Carbofuran; Acetylcholinesterase; Butyrylcholinesterase; Inhibition
• Magazine \ Newspaper: Journal of Biochemical and Molecular Toxicology
• Issue Number: 3
• Volume Number: 28
• Pages: 137 - 142

Publication Abstract

Organophosphates and carbamates are
major agrochemicals that strongly affect different neuroenzymes
and the growth of various fish species.
Here, we study the effect of sublethal concentrations
of profenofos and carbofuran on the activity of
acetylcholinesterase (AChE) and butyrylcholinesterase
(BuChE) and the associated health risk in fish. Labeo
rohita fingerlings were exposed to three sublethal
concentrations of profenofos and carbofuran. Theminimum
cholinesterase activities in the brain, gills, muscle,
kidney, liver, and blood were after exposure to
profenofos (0.06 mg/L). The minimum AChE and
BuChE activities in the brain, gills, muscle, kidney,
liver, and blood were after exposure to carbofuran
(0.28 and 0.198 mg/L). Exposure to both types of pesticides
affected the functions of these organs, including
metabolism and neurotransmission, to various extents
at different exposure concentrations. These findings
suggest that they are required to be properly monitored
in the environment, to reduce their toxic effects
on nontarget organisms C 2014Wiley Periodicals, Inc. J
Biochem Mol Toxicol 28:137–142, 2014; View this article
online at wileyonlinelibrary.com. DOI 10.1002/jbt.21545