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Prof. Khalid Abdullah Al-Ghanem

Professor

Aquatic Ecology and Toxicology

كلية العلوم
أب ٦٨
المنشورات
مقال فى مجلة
2016

Variation in genotoxic susceptibility and biomarker responses in Cirrhinus mrigala and Catla catla from different ecological niches of the Chenab River

Nadeem4, Bilal Hussain1,2 & Tayyaba Sultana1 & Salma Sultana1 & Shahid Mahboob1,3 & K. A. Al-Ghanim3 & Shahid . 2016

DNA fragmentation . Biomarker . Heavy metals . Micronucleus . Genotoxicity

A large number of methods have been applied to evaluate genotoxic damage in different aquatic species. Comet assay, as a method for detecting DNA alterations, and micronucleus test, as an index of chromosomal damage are the most widely used and authentic methods in laboratory and field studies. The primary objective of the study was to evaluate the genotoxic effects of heavy metals generated by toxic industrial effluents and various kinds of pollutants from urban and agricultural areas and domestic waste on Catla catla and Cirrhinus mrigala due to water pollution in the Chenab River, Pakistan. The heavy metals Cd, Cu, Mn. Zn, Pb, Cr, Sn, and Hg were detected by atomic absorption spectrophotometry from water samples collected from predetermined sampling sites. All the physicochemical parameters and heavy metals were found to exceed the upper limits recommended by various agencies. Comet assays showed significant (p < 0.05) DNA damage in C. mrigala compared to C. catla for tail length and olive tail moment from three different sites. Significant (p < 0.05) differences were reported between fish collected from polluted sites and farmed fish, but only nonsignificant (p > 0.05) findings were observed between fish collected from farmed and non-polluted upstream waters. Micronucleus assays showed similar findings for single and double micronucleus induction in C. catla and C. mrigala. A significantly (p< 0.05) higher micronuclei induction and percent tail DNA was observed in C. mrigala specimen collected from the polluted site. These findings infer that DNA damage could be used as a biomarker of pollution load and its early monitoring by using simple and reliable techniques such as the comet and micronucleus assays, expedient methods for toxicity screening of aquatic environments. Regular monitoring is necessary to assess eco-health of the Chenab River by choosing perhaps C. mrigala, being a bottom feeder, as a bioindicator that could provide more reliable information to determine the status of the environmental quality of the river.

نوع عمل المنشور
DNA fragmentation . Biomarker . Heavy metals . Micronucleus . Genotoxicity
رقم المجلد
23
مجلة/صحيفة
Environmental Science and Pollution Research
الصفحات
14589–14599
مزيد من المنشورات
publications

This current work revealed a single-step fabrication of tungsten oxide nanoflakes (WO3
NFs) with the help of Terminalia arjuna bark extract. Bioactive phytoconstituents of T. arjuna bark…

بواسطة Sarinthip Thanakkasaranee 1, Gopinath Kasi 1,*, Sivasamy Kadhiravan 2 , Ayyakannu Arumugam 3, Khalid A. Al-Ghanim 4, Mian Nadeem Riaz 5 and Marimuthu Govindarajan 6,7,*
2023
تم النشر فى:
Sarinthip Thanakkasaranee 1, Gopinath Kasi 1,*, Sivasamy Kadhiravan 2 , Ayyakannu Arumugam 3, Khalid A. Al-Ghanim 4, Mian Nadeem Riaz 5 and Marimuthu Govindarajan 6,7,*
publications

In the present work, the residual biomass of the green seaweed Ulva lactuca was chosen as feedstock to undergo separate
hydrolysis and fermentation process to produce bioethanol. The…

بواسطة Kalavathy Gengiah a,1, Naveenkumar Rajendran b,c,1, Khalid A. Al-Ghanimd, Marimuthu Govindarajan e,f, Baskar Gurunathan a,⁎
2023
تم النشر فى:
Kalavathy Gengiah a,1, Naveenkumar Rajendran b,c,1, Khalid A. Al-Ghanimd, Marimuthu Govindarajan e,f, Baskar Gurunathan a,⁎
publications

Waterbirds may be a good indicator of harmful metal levels in aquatic environments. Waterbirds’
organs and tissues were tested for the presence of pollutants, such as metals. However,

بواسطة Jeganathan Pandiyan 1, Arumugam Poiyamozhi 1, Shahid Mahboob 2, Khalid A. Al-Ghanim 2, Fahad Al-Misned 2, Zubair Ahmed 2, Irfan Manzoor 3 and Marimuthu Govindarajan 4,5,*
2022
تم النشر فى:
Jeganathan Pandiyan 1, Arumugam Poiyamozhi 1, Shahid Mahboob 2, Khalid A. Al-Ghanim 2, Fahad Al-Misned 2, Zubair Ahmed 2, Irfan Manzoor 3 and Marimuthu Govindarajan 4,5,*