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Khalid Ali Alrubeaan

Professor

Director, University Diabetes Center and Strategic Center for Diabetes Research

كلية الطب
University Diabetes Center
المنشورات
مقال فى مجلة
2007
تم النشر فى:

Treatment of Graves’ Hyperthyroidism – Prognostic Factors for Outcome

, Alfadda A1 . 2007

OBJECTIVE:

To determine whether clinical and biochemical features of Graves' disease at presentation predict response to medical and radioiodine treatment.

METHODS:

We carried out a retrospective 10-year study of 194 consecutive Saudi subjects with Graves' disease who were treated with antithyroid drugs, radioiodine therapy, or both, between January 1995 and December 2004 at King Khalid University Hospital, Riyadh, Saudi Arabia.

RESULTS:

At diagnosis, the mean age was 32 +/- 0.9 years. Only 26% of patients had successful outcome after a course of antithyroid medication. None of the clinical or biochemical factors were associated with a favorable outcome of antithyroid treatment. One dose of radioiodine [13-15 mCi (481-555 MBq)] cured hyperthyroidism in 83% of patients. Presence of ophthalmopathy at presentation was shown to be a significant contributing factor to failure to respond to a single dose of radioiodine (odds ratio, 6.4; 95% CI, 1.51-24.4; p<0.01). Failure of radioiodine treatment was also associated with higher serum free T3 concentration at presentation (p=0.003).

CONCLUSION:

In patients with Graves' hyperthyroidism, radioiodine treatment is associated with higher success rate than antithyroid drugs. A dose of 13-15 mCi (481-555 MBq) seems to be practical and effective, and should be considered as first line therapy. Patients with high free T3 concentration and, those with ophthalmopathy at presentation were more likely to fail radioiodine treatment. A higher dose of radioiodine may be advisable in such patients.

نوع عمل المنشور
Research
رقم المجلد
28
رقم الانشاء
2
مجلة/صحيفة
Saudi Medical Journal
الصفحات
225-30
مزيد من المنشورات
publications

Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting that endotoxin, derived from gut flora, may…

2007
publications

BACKGROUND:

This study aims to identify which among the metabolic syndrome (MS) definitions are closely associated with pathological levels of leptin, adiponectin, resistin, tumour necrosis…

بواسطة Al-Daghri NM1, Al-Attas OS, Al-Rubeaan K, Sallam R
2007
publications

Abstract: The aim of the study was to determine surgical indication and complication of subtotal thyroidectomy in patients being treated for Graves’ disease at King Khalid…

بواسطة Usman H , Malabu UH, Assim Alfadda, Riad A. Sulimani, Khalid A. Al-Rubeaan, Atallah D. Al-Ruhaily, Mona A. Fouda, Mohamed A. Al-Maatouq, Abdulkarim A. El-Bakry
2007