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lahssen elblidi

Assistant Professor

Assistant professor

كلية الهندسة
AB 66 Department of Chemical Engineering College of Engineering, King Saud University
المنشورات
مقال فى مجلة
2006
تم النشر فى:

Straightforward chemo-enzymatic synthesis of new aminocyclitols, analogues of valiolamine and their evaluation as glycosidase inhibitors

Lahssen, El Blidi, Mustapha Ahbala, Jean Bolte, Marielle Lemaire, . 2006

chemo-enzymatic synthesis aminocyclitols valiolamine analogues glycosidase inhibitors

An efficient fructose-1,6-bisphosphate aldolase mediated synthesis of new aminocyclitol analogues of valiolamine is described. The one-pot process where four stereocentres are created involves the formation of two carbon–carbon bonds. One is catalysed by the aldolase, coupling dihydroxyacetone phosphate to nitrobutyraldehydes. The other is the result of a highly stereoselective intramolecular Henry reaction occurring on the intermediate nitroketones. Depending on the configuration of the hydroxyl which is a to the nitro group, two series of configuration are accessible. The lipase resolution of the nitroalcohol ketal, precursor of the nitroaldehyde, is presented. The inhibition properties of the aminocyclitols obtained after the reduction of the nitro group are evaluated towards five commercial glycosidases.

نوع عمل المنشور
PHD
رقم المجلد
17
رقم الانشاء
18
مجلة/صحيفة
http://www.sciencedirect.com/science/article/pii/S0957416606006598
الصفحات
2684–2688
مزيد من المنشورات
publications

Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the…

بواسطة Lahssen ElBlidi, Nicolas Vanthuyne, Didier Siri, Stephane Gastaldi, Michele P. Bertrand, Gerard Gil
2010
publications
بواسطة Michele P. Bertrand, Gerard Gil, Stephane Gastaldi, Nicolas Vanthuyne, Malek Nechab, Lahssen El Blidi
2009
publications

A highly stereoselective method for the preparation of nitro and aminocyclitols, using fructose-1,6-bisphosphate aldolase, which catalyzes the aldol reaction of dihydroxyacetone phosphate (DHAP)…

بواسطة Lahssen ElBlidi, Flora Camps Bres, Zeinab Assaf, Henri Veschambre, Vincent Théry, Jean Bolte, Marielle Lemaire
2009