One-pot synthesis of 2,3,4,5,6-pentasubstituted tetrahydropyrans using lithiation–borylation, allylation and Prins cyclisation reactions

Journal Article

⇑, Adeem Mahmood , Jose Ramón Suárez, Stephen P. Thomas, Varinder K. Aggarwal . 2013

• Publication Work Type: PhD
• Publication Online URL: Tetrahedron Letters
• Volume Number: 54
• Pages: 49-51

Publication Abstract

2,3,4,5,6-Pentasubstituted tetrahydropyrans have been prepared in good yield (42–57%) with excellent dr (>95:5) and er (>95:5) using a one-pot lithiation–borylation, allylation and Prins cyclisation reaction.