Oleuropein induces apoptosis via p53 pathway on breast cancer cells
Abstract:
Breast cancer is a major health problem worldwide. Olive oil induces apoptosis in some cancer cells due to its phenolic compounds e.g. oleuropein. Although oleuropein has an anticancer activity, the underlying action mechanism remains unknown. We aim to study the mechanism of oleuropin-induced breast cancer cell apoptosis. P53, Bcl-2 and Bax genes expression were evaluated by Semi-Quantitative Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) in the luminal MCF-7 cells. Oleuropein-induced apoptosis was accompanied by an up-regulation of both p53 and Bax genes expression levels and down-regulation in Bcl2 gene expression level. In conclusion oleuropein induced apoptosis in tumor cells via a p53-dependent pathway mediated by Bax and Bcl2 genes. Therefore, oleuropein may have therapeutic potential in breast cancer patients by inducing apoptosis via activation of p53 pathway.
Keywords: Oleuropein, Breast cancer, apoptotic pathway, p53, Bcl2 and Bax genes
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