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مها حسين الأمين الشيخ

Associate Professor

أستاذ مساعد

كلية العلوم
مبنى 5 الدور الثالث -رقم 100
المنشورات
مقال فى مجلة
2019
تم النشر فى:

Physiological and Histopathological Effects of Artemether in Wistar Rats. Current Science International

, Maha H. Elamin and Ethar . 2019

Original paper

Artemisinin and its derivatives are the most rapidly effective antimalarial drugs. One of the derivatives, artemether is the methyl ether of dihydroartemisinin formulated for treatment of uncomplicated multi-drug resistant falciparum malaria. The aim of the present study is to determine the physiological and histopathological effects of artemether in Wistar rats. Thirty rats were divided into three groups of ten rats each. Group one served as a control. Group two was injected with artemether (25 mg/kg) and group three was injected with artemether (50 mg/kg). Injection was continued daily for a week. At the end of experimental period, blood was collected for determination of Complete Blood Count (CBC). Serum was separated for estimation of biochemical parameters ALT, AST, ALP, Bilirubin, BUN and creatinine. Liver and kidney were removed for hitopathological examination. The results of the present study showed that artemether has no effects on hematological parameters except for haematocrit percent and hemoglobin level when a high dose of artemether was used (50 mg/kg). Rats which were treated with (50 mg/kg) of the drug showed elevated levels of ALT, AST, ALP compared to the control group, however, bilirubin level was comparable to the control group. BUN level was significantly elevated compared to the control group, however, creatinine level was not significantly different from that shown by control group. No histopathological changes were observed in the liver using either low or high dose of the drug. Low dose of artemether showed a wide area of dilatation of the renal tubules in the medullary zone. In addition, extensive vacuolar degeneration was observed in the epithelial cells of the dilated renal tubules. Renal glomeruli have also shown mild congestion. Serious histopathological changes were exhibited by the groups which received high dose of the drug including prominent dilatation of the renal tubules which were fully stuffed and filled with a homogenous eosinophilic proteinaceous material. Furthermore, renal glomeruli were remarkably congested, in addition to swelling of the tubular epithelium

نوع عمل المنشور
Post doc research
رقم المجلد
1
رقم الانشاء
8
مجلة/صحيفة
Current Science International
الصفحات
119-127
مزيد من المنشورات
publications

Abstract Leishmaniasis is a major vector-borne disease triggered by an obligate intracellu-lar protozoan parasite of the genus Leishmania and transmitted by the bite of phlebotominefemale sand…

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Abstract
Hymenolepis nana, typically a parasite found in conventionally established mouse colonies, has zoonotic potential characterized by autoinfection
and direct life cycle. The…

بواسطة 2-Al-Olayan E1, Maha H. Elamin, Alshehri E1, Aloufi A1,2, Alanazi Z1, Almayouf M1, Bakr L3, Abdel-Gaber R
2020
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Abstract
Copepods are a common component of ectoparasite assemblages of all kinds of fish,
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80…

بواسطة Rewaida AbdelGaber, Saleh AlQuraishy1,Mohamed A. Dkhil, Maha H. Elamin, Masheil Alghamdi
2020