PHT 417

This course is designed to provide students with a basic understanding of the principles of biopharmaceutics and pharmacokinetics that can be applied to drug product development and drug therapy. The course is devoted to the exploration and examination of the physical and physic-chemical behavior of drugs, dosage forms, and drug delivery systems in surrounding physiological environments and their implications for pharmaceutical care. Drug absorption processes, bioavailability, and bioequivalence will be highlighted. Pharmacokinetic and pharmacodynamic concepts, including absorption kinetics, distribution, and elimination in the light of compartmental models, will be introduced to the student. Particular emphasis will be placed on understanding, prediction, and utilizing terms such as, clearance, apparent volume of distribution, elimination rate constant, and elimination half life. Prediction of plasma and urine drug concentration based upon pharmacokinetic parameters after single and multiple intravenous and oral doses, as well as after intravenous infusion well be addressed.