Conducting and Biopolymer Based Electrospun Nanofiber Membranes for Wound Healing Applications
Journal Article
Kim, Mohammad R. Karim, Abdurahman Al-Ahmari, M. A. Dar, M.O. Aijaz, M.L. Mollah, P.M. Ajayan, J.H. Yeum and Kil-Soo . 2016
Publication Online URL:
Magazine \ Newspaper:
Current Nanoscience
Volume Number:
11
Pages:
1-7
Publication Abstract:
Conducting polyaniline with o-aminobenzenesulfonic acid copolymer (PAni-co-PABSA) and poly (vinyl alcohol) (PVA)/chitosan oligossacaride (COS) biopolymers based electrospun nanofiber membranes have been exploited for wound healing applications. The nanofiber membranes were assembled by generating two full-thickness skin wounds on the dorsum of SD rats. The PAni-co-PABSA/PVA/COS nanofiber membranes treated wounds show much smaller inflammatory reactions throughout the experimental period. Area of PAni-co-PABSA/PVA/COS nanofiber membranes and commercial (Fucidin®) ointment treated wounds are significantly decreased equate to control treated wounds. Histological appearance after 15 days of treatment with PAni-co-PABSA/PVA/COS nanofiber membranes reveals almost complete healing and an increase in collagen and granulation as compare to control one.