BCH 577 Biochemistry of blood

Review of blood composition. Erythrocyte, leucocytes and platelet composition and metabolism. Hemoglobin and porphyrin metabolism. Metabolism of iron and its storage disorders. Factors affecting blood clotting mechanism. Inherited disorders of hemoglobin (e.g. hemoglobinopathies, porphyrias, sickle cell anemia). Bilirubin metabolism. Hyperbilirubinaemia. Types of white blood cells. Genesis of the white blood cells. Life span of the white Blood cells. Physiological roles of white cells. Inflammation: Role of Neutrophils and Macrophages. Lymphocytes and immunity. Leukocytosis, leukopenia, and other reactive changes of myelopoiesis.

Course Materials