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Dr. MOHAMMAD ABUL FARAH

Assistant Professor

FACULTY

كلية العلوم
Building # 5, Second floor, Lab # 2B 162, Department of Zoology, College of Science, King Saud University, Riyadh
المنشورات
مقال فى مجلة
2018

The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line

Al-Anazi, Mohammad Ibrahim Alallah, Fahad Alhemaid , Fang Bai, Ramzi Ahmed Mothana, Mohamed Soliman Elshikh , Mohammad Abul Farah, Mohammad Ajmal Ali, Joongku Lee , Khalid Mashay . 2018

abstract The alterations in somatic genomes that controls the mechanism of cell division as a main cause of cancer, and then the drug that specifically toxic to the cancer cells further complicates the process of the development of the widely effective potential anticancer drug. The side effects of the drug as well as the radiotherapy used for the treatment of cancer is severe; therefore, the search of the natural products from the sources of wild plants having anticancer potential is become immense importance today. The ethno-medicinal survey undertaken in Al-Fayfa and Wadi-E-Damad region of southern Saudi Arabia revealed that the Caralluma retrospiciens (Ehrenb.) N.E.Br. (family Apocynaceae) is being used for the treatment of cancer by the native inhabitants. The biological evaluation of anticancer potential of bioassay-guided fractionations of methanolic extract of whole plant of C. retrospiciens against human breast adenocarcinoma cell line (MCF-7) followed by characterization using spectroscopic methods confirmed the presence of methyl b-lilacinobioside, a novel active constituent reported for the first time from C. retrospiciens, is capable of inhibition of cell proliferation and induction of apoptosis in MCF-7 cells by regulating ROS mediated autophagy, and thus validated the folkloric claim. Based on a small-scale computational target screening, Topoisomerase II was identified as the potential binding target of methyl b-lilacinobioside.

نوع عمل المنشور
PHD
مجلة/صحيفة
Saudi Journal of Biological Sciences
مزيد من المنشورات
publications

A new SARS coronavirus (SARS-CoV-2) belonging to the genus Betacoronavirus has caused a pandemic known as COVID-19. Among coronaviruses, the main protease (Mpro) is an essential drug…

بواسطة Arun Bahadur Gurung, Mohammad Ajmal Ali, Joongku Lee, Mohammad Abul Farah, Khalid Mashay Al-Anazi
2020
publications

Coronaviruses with the largest viral genomes are positive-sense RNA viruses associated with a history of global epidemics such as the severe respiratory syndrome (SARS), the Middle East…

بواسطة Arun Bahadur Gurung, Mohammad Ajmal Ali, Joongku Lee, Mohammad Abul Farah, Khalid Mashay Al-Anazi
2020
publications

The complete chloroplast genome sequences of vulnerable medicinal plant Saraca asoca (Roxb.) Willd. (Fabaceae) was sequenced. A total of 5,206,216,851 paired-end filtered reads of 151 bp…

بواسطة Mohammad Ajmal Ali, Soo-Yong Kim, Tapan Kumar Pan, F. Al-Hemaid, M. S. Elshikh, Meena Elangbam, Joongku Lee, Mohammad Abul Farah & Khalid M. Al-Anazi.
2020