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Haitham Fady Mohamed Mostafa

Lecturer

Pharmaceutics departmaent

كلية الصيدلة
AB 33/8
المنشورات
مقال فى مجلة
2014
تم النشر فى:

Dextromethorphan Hydrobromide Orally Disintegrating Tablets: Development and Evaluation using Different Formulation Variables

Mostafa, Haitham F. . 2014

Oral disintegrating tablets formulation variables process variables experimental design dextrom

The objective of this work is to develop a simple inexpensive
method for manufacturing dextromethorphan hydrobromide
oral disintegrating tablets (ODTs) and to study the effect of
some formulation variables. Two factors, three levels (32) full
factorial design was used to optimize the diluent, dextrates,
NF (X1) and superdisintegrant, croscarmellose sodium (X2)
concentrations. Disintegration time (Y1), hardness (Y2) and
time required for 50 % release of the drug, T50 (Y3) values for
all the formulations varied from 17.33 to 279.5 s, 3.58 to 4.97
kp and 1.2 to 5 min, respectively. The results indicated that
the selected variables have a strong influence on the selected
responses “disintegration time, hardness and T50” of the ODTs.
The manufactured ODTs formula composed of 30.6 % dextrates
in combination with 4.2 % croscarmellose sodium was
chosen as optimized formula using multiple response optimization.
The predicted and observed values for the optimized
formula showed no significant difference which indicates the
validity of the experimental design. The optimized formula
showed a very significant lower disintegration time and T50
when compared to marketed conventional tablets. Also, it
was compared to pharmburstTM based formula and it showed
a significant higher disintegration time and lower hardness

نوع عمل المنشور
Master
رقم المجلد
76
رقم الانشاء
8
مجلة/صحيفة
Pharmind
الصفحات
1300 to 1310
مزيد من المنشورات
publications

The objective of this work is to develop a simple inexpensive
method for manufacturing dextromethorphan hydrobromide
oral disintegrating tablets (ODTs) and to study the effect of…

بواسطة Haitham F. Mostafa, Mohamed A. Ibrahima, Adel Sakr
2014
publications

Orally disintegrating tablets (ODTs), which disintegrate rapidly (<1 min) in the mouth and do not require water for administration, have become a very popular dosage form. The study aims to…

بواسطة Haitham Fady Mostafa, Mohamed Abbas Ibrahim, Adel Sakr
2013
publications

Pantoprazole sodium sesquihydrate (PSS) is a proton pump inhibitor, used in acid-related disorders, like peptic ulcer and gastroesophageal reflux. Increasing the number of pantoprazole containing…

بواسطة Haitham F. Mostafa, Mohamed A. Ibrahima, Gamal M. Mahrous, Adel Sakr
2011