Targeting doxorubicin encapsulated in stealth liposomes to solid tumors by non-thermal diode laser.

Journal Article

, Magdy M. Ghannam, Reem El Gebaly and Maha Fadel . 2116

• Publication Work Type: Research Work
• Magazine \ Newspaper: Lipids in Health and Disease.
• Issue Number: 68
• Volume Number: 15 (68)
• Pages: 2-8

Publication Abstract

Background: The use of liposomes as drug delivery systems is the most promising technique for targeting drug
especially for anticancer therapy.
Methods: In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated
doxorubicin. The effect of lyophilization on liposomal stability and hence expiration date were studied. Moreover,
the effect of diode laser on the drug released from liposomesin vitro and in vivo in mice carrying implanted solid
tumor were also studied.
Results: The results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to
marked stability when stored at 5 °C and it is possible to use the re-hydrated lyophilized liposomes within 12 days
post reconstitution. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells is
a promising method in cancer therapy.
Conclusion: We can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked
stability for the liposomes when stored at 5°C. Moreover, the use of low energy diode laser for targeting anticancer
drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is
a promising method. It proved to be applicable and successful for treatment of Ehrlich solid tumors implanted in
mice and eliminated toxic side effects of doxorubicin.