Single Blinded Randomized Controlled Clinical Trial on the Efficacy of Ozone Therapy on Breast Cancer-Related Lymphedema. Cancer and Clinical Oncology2013; 2 (2):93-106.
, 2. Intsar S. Waked, Samah H. Nagib & Mohammed T. A. Omar. . 2013
Purpose: The purpose of this study was to evaluate the efficacy of ozone therapy in breast cancer-related
Lymphedema (BCRL).
Methods: Sixty patients with BCRL were participated in this study and were randomly assigned to one of two
groups. Ozone group received ozone therapy in addition to complex physical therapy for lymphedema consisted
of pressure garment, remedial exercise, and skin care, while the control group received complex physical therapy
only. Limb volume was measured using water displacement and limb circumference. Skin and subcutaneous
thickness were measured using Doppler ultrasound. All measurements were carried out at baseline (0wk) and
after 12 weeks (12wk) of intervention.
Results: The clinical and demographic characteristics of both groups were comparable at baseline. The reduction
of limb volume tended to decline in both groups. The trend was more significantly pronounced in ozone group
than control at 12 wk (P < 0.05). There was significant reduction in skin and subcutis thickness in both groups.
The rate of thickness reduction was more observable in the ozone group than the control group.
Conclusion: Ozone therapy was found to be an effective adjunctive modality for reducing limb volume and
thickness in the women with BCRL.
