Impact of tributyltin on antioxidant and DNA damage response in spermatozoa of freshwater prawn Macrobrachium rosenbergii

Journal Article

Rani, K. Umaa . 2015

• Publication Online URL: https://link.springer.com/article/10.1007/s11356-015-5202-3
• Magazine \ Newspaper: Environ Sci Pollut Res
• Issue Number: 24
• Volume Number: 22
• Pages: 20000–20006

Publication Abstract

Effects of tributyltin (TBT) on antioxidant [total

superoxide dismutase (SOD), glutathione peroxidase (GPx),

and glutathione reductase (GR)] and DNA damage levels in

the spermatozoa were studied and reported here for the first

time in the freshwater prawn Macrobrachium rosenbergii.

Three groups of (n=10 in each group) fishes were exposed

to three different nominal concentrations of TBT viz., 1, 2, and

4 mg L−1 along with control group for 90 days. Significant

decrease of antioxidant and increased DNA damage levels

were seen at higher doses of 2 and 4 mg L−1. In prawn, the

antioxidant level plays a vital role in sperm protection, activation,

differential functions related to the physiology, and reproductive

behavior. This study serves as a biomonitoring tool

to assess the TBT effects on reproductive behavior of aquatic

biota.