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أمــل بنت محمد بن عبدالعزيز المحيميد

Associate Professor

استاذ مشارك- مساعدة وكيلة كلية العلوم للدراسات العليا والبحث العلمي

كلية العلوم
مبنى 5- الدور الثالث- مكتب رقم 188
المنشورات
مقال فى مجلة
2012

New Coated Wire Sensors for Potentiometric Determination of Gemifloxacin in Pure Form, Pharmaceutical Formulations and Biological Fluids

, Amal M. Al-Mohaimeed*, Salma A. Al-Tamimi, . 2012

ورقة بحثيه

A simple, accurate and precise potentiometric method was developed for the determination of gemifloxacin mesylate (GFX). Three ion selective coated wire sensors have been constructed from the incorporation of (GFX) with the ion-pairing agents phosphotungstic acid (PTA), phosphomolybdic acid (PMA) and Ammonium reineckate salt (ARS). The three sensors show nearly Nernestian response over the concentration range 1.0x10−7-1.0 x10−2 mol L-1 of the drug with slopes of 56.14±0.08, 57.66±0.14 and 55.06±0.32 mV decade-1 for (GFX-PTA), (GFX-PMA) and (GFX-ARS) coated wire sensors, respectively. The electrodes exhibit a fast dynamic response of 30, 15 and 20 s for a period of 30, 35 and 25 days for  (GFX-PTA), (GFX-PMA) and (GFX-ARS) coated wire sensors, respectively. The sensors exhibit good selectivity for GFX with respect to some inorganic cations, amino acids and some pharmacologically related compounds. The electrodes display stable potential response in the pH range 6-9 which indicates the applicability of these electrodes in the specified range. The method is accurate and precise as indicated by the mean % recoveries 99.49±0.52, 99.56±0.41 and 99.41±0.45 for (GFX-PTA), (GFX-PMA) and (GFX-ARS) coated wire sensors, respectively. The proposed method was successfully applied for the determination of GFX in pure form, its pharmaceutical formulations and biological fluid

نوع عمل المنشور
دكتوراه
رقم المجلد
7
رقم الانشاء
7
مجلة/صحيفة
International Journal of ELECTROCHEMICAL SCIENCE
الصفحات
12518 - 12530
مزيد من المنشورات
publications

: A simple, rapid and highly sensitive spectrofluorimetric method was developed for determination of gemifloxacin mesylate (GFX) in tablets. The method is based on measuring the native fluorescence…

بواسطة Amal M. Al-Mohaimeed*, Salma A. Al-Tamimi, , Nawal A. Alarfaj, Fatma A. Aly
2014
publications

A simple, accurate and precise potentiometric method was developed for the determination of gemifloxacin mesylate (GFX). Three ion selective coated wire sensors have been constructed from the…

بواسطة Amal M. Al-Mohaimeed*, Salma A. Al-Tamimi, , Nawal A. Alarfaj, Fatma A. Aly
2012
publications

 

بواسطة Salma A. Al-Tamimi, Amal M. Al-Mohaimeed*, Nawal A. Alarfaj, Fatma A. Aly
2013