Thermodynamics of solubility of ibrutinib in ethanol + water cosolvent mixtures at different temperatures
Haq, Faiyaz Shakeel , Muzaffar Iqbal, Essam Ezzeldin, Nazrul . 2015
According to literature, ibrutinib (IBR) is a practically insoluble drug in water. The practically insoluble nature of
IBR creates several problems in dosage form design of IBR. Hence, in thiswork, the thermodynamics of solubility
of IBR in various ethanol + water cosolvent mixtures was studied. The solubility of crystalline IBR was
determined at T = (298.15 to 323.15) and p = 0.1 MPa using an isothermal method. The measured solubility
data of crystalline IBR were correlated well with three semiempirical models namely Van't Hoff, the modified
Apelblat and Yalkowsky models. The solubility of crystalline IBR was observed highest in pure ethanol (mole
fraction solubility: 3.12 × 10−3 at T = 298.15 K) and lowest in pure water (mole fraction solubility:
1.42 × 10−7 at T = 298.15 K) over the entire temperature range investigated. Thermodynamic parameters of
crystalline IBR were determined by Van't Hoff and Krug et al. analysis and results indicated an endothermic,
spontaneous and an entropy-driven dissolution of crystalline IBR in all ethanol + water cosolvent mixtures.
