المنشورات و المؤلفات
The IL-6/STAT3/NF-κB positive feedback loop links in ammation to cancer and maintains cells at a transformed state. Similarly, cancer-associated myo broblats remains active even in absence of cancer cells. However, the molecular basis of this...
Breast cancer is a major health problem that threatens millions of women’s lives each year worldwide. Cancer-associated fibroblasts (CAFs), which constitute the major component of the tumor stroma, have been reported to actively contribute to tumor...
Increasing evidence support the critical roles of active stromal fibroblasts in breast cancer development and spread. However, the mediators and the mechanisms of regulation are still not well defined. We have shown here that the tumor suppressor...
Background: Active cancer-associated fibroblasts (CAFs) or myofibroblasts play important roles not only in the development and progression of breast carcinomas, but also in their prognosis and treatment. Therefore, targeting these cells through...
http://cancerres.aacrjournals.org/cgi/content/meeting_abstract/70/24_MeetingAbstracts/P4-05-02