Synthesis, Characterization, and Anti-Cancer Activity of Some New N′-(2-Oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazones Derivatives

Journal Article

Abutaha, Nael . 2015

• المجلة \ الصحيفة: Molecules
• رقم العدد: 20
• الصفحات: 14638-14655

مستخلص المنشور

Eight novel N′-(2-oxoindolin-3-ylidene)-2-propylpentane hydrazide-hydrazone

derivatives 4a–h were synthesized and fully characterized by IR, NMR (1H-NMR and
13C-NMR), elemental analysis, and X-ray crystallography. The cyto-toxicity and in vitro
anti-cancer evaluation of the prepared compounds have been assessed against two different
human tumour cell lines including human liver (HepG2) and leukaemia (Jurkat), as well as
in normal cell lines derived from human embryonic kidney (HEK293) using MTT assay.
The compounds 3e, 3f, 4a, 4c, and 4e revealed promising anti-cancer activities in tested human
tumour cells lines (IC50 values between 3 and 7 μM) as compared to the known anti-cancer
drug 5-Fluorouracil (IC50 32–50 μM). Among the tested compounds, 4a showed specificityagainst leukaemia (Jurkat) cells, with an IC50 value of 3.14 μM, but this compound was
inactive in liver cancer and normal cell lines.